2017 RECONNECT TRIAL Reconnection to mechanical ventilation (MV) for 1h after a successful spontaneous breathing trial (SBT) reduces reintubation in critically ill patients. Parallel, two-arm, prospective randomised controlled trial Objective: To evaluate the reduction in need for reintubation in critically ill patients who pass a SBT by 1-hour rest compared with immediate extubation (control) 470 […]
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LOVIT Trial Summary: IV Vitamin C in Septic Shock
2022 LOVIT TRIAL Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit Randomized, placebo-controlled trial Objective: To assess the use of intravenous vitamin C in a dults with sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) 872 patients 872 Inclusion Criteria: adults who had been in the ICU […]
Early Palliative Care in Patients with Lung Cancer Trial
2010 EARLY PALLIATIVE CARE M Early Palliative Care for Patients with Metastatic Non-Small-cell Lung Cancer Single-center, Prospective, non-blinded, parallel-group, randomized, control Objective: In patients with metastatic NSCLC, how does the early introduction of palliative care affect the quality of life? 151 patients Inclusion Criteria: Ambulatory Patients with pathologic diagnosis of NSCLC in prior 8 weeks. […]
ACTION Trial: Anticoagulation in COVID-19
2021 ACTION TRIAL Therapeutic vs. prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer Pragmatic, open-label (with blinded adjudication), multicentre, randomised Objective: to evaluate therapeutic anticoagulation compared with prophylactic anticoagulation among patients admitted with coronavirus disease 2019 (COVID-19) infection. 615 patients Inclusion Criteria: Patients (aged >18 years) hospitalised with COVID-19 and elevated […]
POISE-3 Trial Summary: Tranexamic Acid in Noncardiac Surgery
2022 POISE-3 TRIAL МІ Tranexamic Acid in Patients Undergoing Noncardiac Surgery International, randomized, controlled trial Objective: In patients undergoing noncardiac surgery who are at risk for bleeding and CV events, does tranexamic acid lowers incidence of major bleeding when compared to placebo and is it noninferior to placebo with respect to the incidence of major […]
CHAP Trial Summary: Chronic Hypertension in Pregnancy
2022 CHAP TRIAL Treatment for Mild Chronic Hypertension during Pregnancy Open-label, multicenter, randomized trial Objective: To assess if treating mild chronic hypertension during pregnancy with a BP goal of <140/90 mmHg would lower incidence of adverse maternal and perinatal outcomes than a strategy of withholding treatment until the BP was 160/105 mm Hg or higher […]
DISCHARGE Trial Summary: CT or Angio in Stable Chest Pain
2022 DISCHARGE TRIAL Summary: CT or Invasive Coronary Angiography in Stable Chest Pain- Pragmatic, randomized controlled trial- Objective: To evaluate computed tomography (CT) compared with invasive coronary angiography among patients with stable chest pain and intermediate pretest probability of obstructive coronary artery disease- 3561 patients- Inclusion Criteria: -At least 30 years of age -Stable chest […]
UK TAVI Trial Summary: TAVI in Moderate Aortic Stenosis
2022 UK TAVI TRIAL M Effect of TAVI vs Surgical Aortic Valve Replacement on All-Cause Mortality in Patients With Aortic Stenosis Multicenter, randomized controlled trial – Objective: To assess if TAVI is non-inferior to surgical aortic valve replacement in patients aged 70 years or older with severe, symptomatic aortic stenosis and moderately increased operative risk? […]
Infographic: Pregnancy and Cardiovascular Disease
PARADISE MI Trial Summary: Sacubitril-valsartan vs ramipril in acute MI
2021 PARADISE-MI M Angiotensin Receptor-Neprilysin Inhibition in Acute Myocardial Infarction international, multicenter, randomized, double-blind, active-comparator trial S S 1. Objective: To compare the effects of sacubitril-valsartan and angiotensin converting-enzyme inhibitor, ramipril in patients with acute myocardial infarction 5661 Inclusion criteria: Adults without history of heart failure but spontaneous myocardial infarction with a reduced left ventricular […]