Author Archives: admin

VISION Trial Summary: Lutetium 177 PSMA 617 for Metastatic Prostate Cancer

2021 VISION TRIAL Lutetium-177-PSMA-617 for metastatic castration-resistant prostate cancer Prospective, open-label, randomized, international, phase 3 trial Objective: To evaluate Lutetium-177 (177Lu)-PSMA-617 a radioligand therapy along with standard care in Prostate-specific membrane antigen (PSMA) positive metastatic castration-resistant prostate cancer as compared … Read More

SECURE Trial Summary: Polypill Strategy in Secondary Cardiovascular Prevention

2022 SECURE TRIAL Polypill Strategy in Secondary Cardiovascular Prevention Phase 3, randomized, controlled clinical trial Objective: To evaluate the effect of polypill that includes key medications (aspirin, ramipril, and atorvastatin) on cardiovascular events in post-Ml patients. 2499 Inclusion criteria: Patients … Read More

TTM 48 Trial Summary: TTM for 48 hours in Cardiac Arrest

2017 2017 TTM 48 TRIAL M Targeted Temperature Management for 48 vs 24 hours and neurologic outcome after out-of-Hospital Cardiac Arrest (OOHCA) Multicenter,blinded,parallel,pragmatic,randomized superiority trial Objective: To determine neurologic outcomes with Targeted Temperature Management (TTM) at 33°C for 48 hours … Read More

REDECAP Trial Summary: High-Flow Oxygen for Tracheostomy Decannulation

2020 REDECAP TRIAL M High-flow oxygen with capping or suctioning for tracheostomy decannulation Multicentre randomised controlled trial So Objective: To compare an assessment of readiness for decannulation that is based on suctioning frequency with an assessment based on tracheostomy capping … Read More

ATESS Trial Summary: Vitamin C + Thiamine for Septic Shock

2020 ATESS TRIAL Combination therapy of vitamin C and thiamine for septic shock Multicentre, double-blind, randomized controlled trial Objective: To evaluate the effects of early combination therapy with intravenous vitamin C and thiamine on recovery from organ failure in patients … Read More

PSP Trial Summary: Interventional Treatment for Spontaneous Pneumothorax

2020 PSP TRIAL M Conservative versus interventional treatment for spontaneous pneumothorax Prospective, randomized control, non-inferiority trial Objective: To assess whether conservative management compared to interventional treatment results in acceptable rates of lung re-expansion at 8 weeks in patients with primary … Read More

FIESTY Trial Summary: Fibrinogen in Severe Trauma

2021 FEISTY TRIAL Fibrinogen early in severe trauma study | multicentre, randomized controlled pilot study s Objective: To compare the time to fibrinogen replacement using f ibrinogen concentrate (FC) or cryoprecipitate (Cryo) in severely injured trauma patients with major hemorrhage … Read More

COBI Trial Summary: Hypertonic Saline in Traumatic Brain Injury

2021 COBI TRIAL M Effect of continuous infusion of hypertonic saline vs standard care on 6-month neurological outcomes in patients with traumatic brain injury multicenter, parallel-group, open-label, randomized clinical trial Objective: To assess whether continuous infusion of 20% hypertonic saline … Read More

LOCO2 Trial Summary: Oxygen Therapy in ARDS

2020 2020 LOCO2 TRIAL M Liberal or conservative oxygen therapy for Acute Respiratory Distress Syndrome Multicentre, randomised controlled trial Objective: To assess whether in patients with Acute Respiratory Distress Syndrome (ARDS), does conservative (Target PaO2:55-70mmHg; SpO2: 88-92%) vs. liberal (Target … Read More

VITAMINS Trial: Vitamin C, hydrocortisone, and thiamine in Septic Shock

2021 2021 VITAMINS TRIAL M Effect of Vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock Open label, multi-centre, randomized, phase IIb clinical trial Objective: To investigate whether … Read More