2020 ARREST 2020 TRIAL M Advanced reperfusion strategies for patients with out-of hospital cardiac arrest (OHCA) and refractory ventricular fibrillation (VF) Phase 2, single center, open-label, randomized clinical trial Objective: To compare implementation of early ECMO facilitated resuscitation compared to … Read More
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SURMOUNT-1 Trial: Tirzepatide for Weight Loss in Obesity
2022 SURMOUNT-1 TRIAL M Tirze patide Once Weekly for the Treatment of Obesity Phase 3 double-blind, randomized, controlled trial Objective: To assess the efficacy and safety of tirzepatide, a novel glucose-dependent insulinotropic polypeptide and GLP-1 agonist, in treatment of obesity … Read More
MR CLEAN-NO IV Trial Summary: IV Alteplase before Endovascular Therapy in Stroke
2021 MR CLEAN-NO IV TRIAL M 2021 A Randomized Trial of Intravenous Alteplase before Endovascular Treatment(EVT) for Stroke investigator-initiated, international, multicenter, prospective, randomized, open-label trial ” d Objective: To determine whether EVT alone would be more effective, or noninferior, as … Read More
KEYNOTE-826 Trial Summary: Pembrolizumab in Metastatic Cervical Cancer
2021 KEYNOTE-826 TRIAL Pembrolizumab for Persistent, Recurrent, or Metastatic Cervical Cancer double-blind, phase 3, randomized controlled trial Objective: To assess whether adding pembrolizumab to platinum-based chemotherapy with or without bevacizumab would improve efficacy as compared with chemotherapy with or without … Read More
EMPULSE Trial Summary: Empagliflozin in Acute Heart Failure
2021 EMPULSE TRIAL Empagliflozin in patients hospitalized for Acute Heart Failure Randomized, parallel trial Objective: To evaluate empagliflozin compared with placebo among patients with acute decompensated heart failure. 530 patients Inclusion criteria: Patients hospitalized for acute HF regardless of ejection … Read More
AVATAR Trial Summary: AVR in Asymptomatic Severe Aortic Stenosis
2021 AVATAR TRIAL M Aortic Valve replacement versus Conservative treatment in asymptomatic severe Aortic Stenosis Parallel, Randomised controlled trial Objective: To evaluate aortic valve replacement (AVR) compared with conservative therapy among patients with asymptomatic severe aortic stenosis 157 Inclusion criteria: … Read More
PALACS Trial Summary: Posterior Left Pericardiotomy for Post-op AFib
2021 PALACS TRIAL M Posterior left pericardiotomy for the prevention of postoperative atrial fibrillation after cardiac surgery Randomized, parallel, stratified, single-centre study Objective: To evaluate posterior left pericardiotomy compared with no intervention among patients undergoing open heart surgery 420 patients … Read More
ANTHARTIC Trial Summary: Prevention of Ventilator-Associated Pneumonia after Cardiac Arrest
2019 ANTHARTIC TRIAL M Prevention of early Ventilator-Associated Pneumonia after cardiac arrest Multicentre, randomised, double-blind, placebo-controlled Objective: To investigate whether in post out-of-hospital cardiac arrest (OOHCA) patients treated with targeted temperature management, does the use of empirical antibiotics prevent early … Read More
Beta Blockers in Traumatic Brain Injury Trial Summary
2020 BETA-BLOCKER THERAPY IN TBI Beta-Blocker Therapy in Severe Traumatic Brain Injury (TBI) Single-center,non-blinded,randomized controlled trial d d Objective: To examine the effect of beta-blockers on outcomes in TBI patients. 154 patients Patients > 18 years with: -blunt head trauma … Read More
NONSEDA Trial Summary: Sedation in Critically Ill Intubated Patients
2020 NONSEDA TRIAL M Nonsedation or light sedation in critically ill, mechanically ventilated patients Investigator-initiated, randomised, clinical, parallel-group, multinational, superiority trial . a 5 Objective: To assess whether in critically ill, mechanically ventilated patients, does a strategy of no sedation, … Read More