2021 AMPLITUDE-O TRIAL M Cardiovascular and renal outcomes with efpeglenatide in type 2 diabetes international, randomized, controlled trial Objective: To evaluate efpeglenatide in participants with type 2 diabetes and either a history of cardiovascular disease or current kidney disease 4076 … Read More
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AMPLIFY Trial: Apixaban for acute VTE
2013 AMPLIFY TRIAL Oral Apixaban for the Treatment of Acute Venous Thromboembolism double-blind, multicenter, randomized controlled trial IM Objective: To determine if apixaban is non-inferior to conventional therapy with LMWH in patients with pulmonary embolism or proximal deep venous thrombosis … Read More
AMBITION Trial: Liposomal amphotericin B in Cryptococcal meningitis
2022 AMBITION TRIAL Single-dose liposomal amphotericin B treatment for cryptococcal meningitis Open-label, phase 3, non inferiority, randomized controlled trial M Objective: To determine the efficacy and safety of single high dose (10mg/kg) of liposomal amphotericin B in HIV-positive adults with … Read More
Wolf-Parkinson-White (WPW) Syndrome: Infographic
Wolff-Parkinson-White (WPW) Syndrome Characterized by presence of accessory pathway (bundle of Kent) between atria and ventricle that can cause “preexcitation” or earlier activation of the His-Purkinje system. ECG Features Delta wave: slow muscle- fiber-to-muscle-fiber conduction WPW pattern: Preexcitation pattern on … Read More
VICTAS Trial: Vitamin C, Thiamine, and Hydrocortisone in Sepsis
2021 VICTAS TRIAL IM Effect of vitamin C, thiamine, and hydrocortisone on ventilator-and vasopressor-free days in patients with sepsis multicenter, double-blind, randomized controlled trial Objective: To determine whether combination of vitamin C, thiamine & hydrocortisone every 6 hours increases ventilator- … Read More
ISCHEMIA Trial: Invasive or Medical therapy for Stable CAD
2020 ISCHEMIA TRIAL M Initial Invasive or Conservative Strategy for Stable Coronary Disease multicenter, parallel, randomized controlled trial Objective: Tto determine the effect of adding cardiac catheterization (hereafter, angiography) and revascularization when feasible to medical therapy in patients with stable … Read More
SINGLE Trial: Dolutegravir in HIV
2013 SINGLE TRIAL M Dolutegravir plus abacavir-lamivudine for the treatment of HIV-1 infection double-blind, randomized controlled trial 844 Objective: To assess the safety & efficacy of dolutegravir at a dose of 50 mg plus a fixed-dose combination of abacavir-lamivudine, as … Read More
BEHoLD Trial: Entecavir + Lamivudine for Hep B
2006 BEHOLD TRIAL A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B multicenter, double-blind, double-dummy, randomized controlled trial M Objective: To compare the efficacy and safety of 48 weeks of therapy with entecavir with 48 weeks of therapy … Read More
BASICS Trial: Endovascular Therapy for Basilar Stroke
2021 BASICS TRIAL Endovascular therapy for stroke due to basilar-artery occlusion multicenter, open-label, randomized controlled trial M Objective: To determine effectiveness of endovascular therapy in patients with stroke caused by basilar-artery occlusion. 300 patients. Inclusion criteria: Patients aged ≥ 18 … Read More
MADIT-CRT Trial Summary: CRT in HF
2009 MADIT-CRT TRIAL Cardiac-Resynchronization Therapy for the prevention of heart-failure events multicenter, open-label, randomized controlled trial Objective: To determine whether cardiac-resynchronization therapy with implantable cardioverter-defibrillator (CRT-ICD) would reduce the risk of death or heart-failure events in M patients with mild … Read More