2015 ANRS IPERGAY TRIAL On-demand preexposure prophylaxis in men at high risk for HIV-1 infection Multicenter randomized, placebo controlled trial Objective: To assess if on-demand pre-exposure prophylaxis around the time of sex reduce the transmission of HIV Among men who … Read More
Infectious Diseases
ANDROMEDA SHOCK Trial: Resuscitation in Septic Shock
ANDROMEDA-SHOCK: Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels in Septic Shock Multicenter, randomized trial conducted at 28 intensive care units in 5 countries 424 patients with septic shock were randomized to to a step-by-step … Read More
AMBITION Trial: Liposomal amphotericin B in Cryptococcal meningitis
2022 AMBITION TRIAL Single-dose liposomal amphotericin B treatment for cryptococcal meningitis Open-label, phase 3, non inferiority, randomized controlled trial M Objective: To determine the efficacy and safety of single high dose (10mg/kg) of liposomal amphotericin B in HIV-positive adults with … Read More
SINGLE Trial: Dolutegravir in HIV
2013 SINGLE TRIAL M Dolutegravir plus abacavir-lamivudine for the treatment of HIV-1 infection double-blind, randomized controlled trial 844 Objective: To assess the safety & efficacy of dolutegravir at a dose of 50 mg plus a fixed-dose combination of abacavir-lamivudine, as … Read More
AMAZES Trial Summary: Azithromycin in Asthma
2017 AMAZES TRIAL Azithromycin in asthma exacerbations Multicenter, double-blind, placebo controlled parallel group trial M Objective: In adult patients with symptomatic asthma who are currently using an inhaled corticosteroid or a long-acting bronchodilator, does oral azithromycin decrease the frequency of … Read More
AIDA-WP2 Trial Summary: Fosfomycin or Nitrofurantoin in UTI
2018 AIDA-WP2 Effect of 5-Day nitrofurantoin vs single-dose fosfomycin on M clinical resolution of uncomplicated lower urinary tract infection in women Multinational, open-label, analyst-blinded, randomized clinical trial Objective: To compare the clinical and microbiologic efficacy of nitrofurantoin and fosfomycin in … Read More
ACTT-2 Trial Summary: Baricitinib + Remdesivir in Covid-19
2020 ACTT-2 TRIAL Baricitinib plus Remdesivir for Hospitalized Adults with Covid-1 Double-blind, randomized, placebo-controlled trial M Objective: To compare the clinical efficacy of combination of baricitinib plus remdesivir with remdesivir alone among hospitalized adults with laboratory-confirmed Covid-19. 1033 patients Patients … Read More
ACTT-1 Trial Summary: Remdesivir in Covid-19
2020 ACTT-1 TRIAL Remdesivir for the Treatment of Covid-19 Double-blind, randomized, placebo-controlled trial Objective: To evaluate the clinical efficacy and safety of putative investigational therapeutic agent remdesivir among hospitalized adults with laboratory-confirmed Covid-19. M Patients with lab-confirmed SARS-CoV-2 infection 1,063 … Read More
ACTT-4 Trial Summary: Baricitinib in Covid-19
2022 ACTT-4 TRIAL Baricitinib versus dexamethasone for adults hospitalised with COVID-19 double-blind, double placebo-controlled, randomised controlled trial M Objective: To compare baricitinib in combination with remdesivir versus dexamethasone with remdesivir at preventing progression to mechanical ventilation or death 1010 patients … Read More
ACTIV-4B Trial Summary: Antithrombotic Therapy in Covid-19
2021 ACTIV-4B TRIAL Effect of antithrombotic therapy on clinical outcomes in outpatients with clinically stable symptomatic COVID-19 minimal-contact, adaptive, randomized, double-blind, placebo-controlled Objective: To assess whether anticoagulant or antiplatelet therapy can safely reduce major adverse cardiopulmonary outcomes among symptomatic but … Read More