The ACTIV-6 trial, published in the New England Journal of Medicine in 2023, examines the effectiveness of inhaled fluticasone furoate in the treatment of non-hospitalized patients with mild to moderate COVID-19. The trial was a decentralized, double-blind, randomized, placebo-controlled study … Read More
Infectious Diseases
ACT HIV Trial: Dexamethasone in TB Meningitis
ACT HIV TRIAL (2023) Summary and Key Points In 2023, a significant study titled the “ACT HIV TRIAL” was published, which delved into the potential benefits of using adjunctive dexamethasone for the treatment of tuberculous meningitis in HIV-positive adults. This … Read More
ASAP Trial: Vancomycin and Cefazolin in Arthroplasty Prophylaxis
The ASAP Trial: Vancomycin and Cefazolin in Arthroplasty Prophylaxis – An Analysis The realm of surgical prophylaxis has always been a topic of deep medical interest, aiming to prevent complications and ensure the best outcomes for patients. One such endeavor … Read More
AMIKINHAL Trial: Inhaled Amikacin in Preventing VAP
The medical world is continually seeking innovative methods to combat and prevent life-threatening conditions. One such condition is ventilator-associated pneumonia, a severe complication that affects patients undergoing mechanical ventilation. The recent AMIKINHAL trial, a multicenter, double-blind, randomized, controlled, superiority study, … Read More
VITAMINS Trial Summary: Vit. C in Septic Shock
VITAMINS Trial Summary The VITAMINS trial aimed to determine whether the combination of vitamin C, hydrocortisone, and thiamine is more effective than hydrocortisone alone in expediting the resolution of septic shock. The trial included 216 patients with septic shock and … Read More
WRAP-IT Trial: Utilizing Antibiotic-Eluting Envelopes to Reduce Infections After Cardiac Device Implantation
WRAP-IT Trial Summary Infections following the placement of cardiac implantable electronic devices (CIEDs) can lead to significant morbidity and mortality. Although preoperative antibiotics are a standard prophylactic strategy, evidence for other preventive approaches is limited. The WRAP-IT trial sought to … Read More
ANTHARTIC Trial: Preventing VAP after CA
2019 ANTHARTIC TRIAL M Prevention of early Ventilator-Associated Pneumonia after cardiac arrest Multicentre, randomised, double-blind, placebo-controlled Objective: To investigate whether in post out-of-hospital cardiac arrest (OOHCA) patients treated with targeted temperature management, does the use of empirical antibiotics prevent early … Read More
ANRS IPERGAY Trial: Prophylaxis in men at risk of HIV
2015 ANRS IPERGAY TRIAL On-demand preexposure prophylaxis in men at high risk for HIV-1 infection Multicenter randomized, placebo controlled trial Objective: To assess if on-demand pre-exposure prophylaxis around the time of sex reduce the transmission of HIV Among men who … Read More
ANDROMEDA SHOCK Trial: Resuscitation in Septic Shock
ANDROMEDA-SHOCK: Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels in Septic Shock Multicenter, randomized trial conducted at 28 intensive care units in 5 countries 424 patients with septic shock were randomized to to a step-by-step … Read More
AMBITION Trial: Liposomal amphotericin B in Cryptococcal meningitis
2022 AMBITION TRIAL Single-dose liposomal amphotericin B treatment for cryptococcal meningitis Open-label, phase 3, non inferiority, randomized controlled trial M Objective: To determine the efficacy and safety of single high dose (10mg/kg) of liposomal amphotericin B in HIV-positive adults with … Read More