High levels of triglycerides, a type of fat found in the blood, have been connected to an increased risk of cardiovascular diseases. The question of whether decreasing these levels can reduce the incidence of cardiovascular events has been under investigation. Pemafibrate, a selective peroxisome proliferator–activated receptor α modulator, has been shown to lower triglyceride levels […]
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SUNLIGHT Trial: Prolonging Survival for Advanced Colorectal Cancer Patients with Trifluridine–Tipiracil and Bevacizumab
The groundbreaking “SUNLIGHTTrial” recently highlighted the potential of the combined treatment of Trifluridine–Tipiracil (FTD–TPI) and Bevacizumab in extending the lifespan of patients with advanced colorectal cancer. The promising phase 3 study builds on prior research suggesting the efficacy of FTD–TPI in these cases, and points to the enhanced potential of FTD–TPI when used in combination […]
Navigating the Controversy: A Comprehensive Review of Landmark Clinical Trials on Steroids Use in Septic Shock
Explore the pivotal clinical trials that have shaped our understanding of the role of steroids in the management of septic shock, unveiling the complexities and nuances of this controversial topic. Introduction Septic shock is a life-threatening condition characterized by a dysregulated host response to infection, leading to circulatory and metabolic abnormalities. The use of steroids […]
A New Frontier in Heart Failure Management: A Comprehensive Review of Landmark Clinical Trials on SGLT2 Inhibitors
Explore the transformative clinical trials that have solidified the role of SGLT2 inhibitors in heart failure management and their potential to redefine the treatment landscape. Introduction Heart failure is a complex clinical syndrome associated with significant morbidity and mortality. In recent years, sodium-glucose cotransporter-2 (SGLT2) inhibitors have emerged as a promising new class of drugs […]
Navigating the New Era: Landmark Clinical Trials on Eliquis (Apixaban) for Anticoagulation in Atrial Fibrillation
Atrial fibrillation (AFib) is a prevalent cardiac arrhythmia that significantly elevates the risk of stroke and systemic embolism. As a result, effective anticoagulation therapy is crucial for managing AFib patients. Over the past decade, novel oral anticoagulants (NOACs) have challenged traditional vitamin K antagonists, like warfarin, as preferred therapeutic options. Eliquis (apixaban) is one such […]
Pioneering the Path: Key Landmark Trials on Ablation Procedures for Atrial Fibrillation
Delve into the pivotal clinical trials that have shaped our understanding and management of atrial fibrillation through ablation procedures.
The Data Behind HFpEF Management: Landmark Clinical Trials on Heart Failure with Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) is a complex and increasingly prevalent form of heart failure, accounting for nearly half of all heart failure cases. Despite its significance, HFpEF remains a challenging condition to manage and treat, as effective therapies have been limited. In this article, we delve into the landmark clinical trials that […]
APAF Trial: Ablation or Antiarrhythmics for PAF
2006 APAF STUDY A randomized trial of circumferential pulmonary vein ablation versus antiarrhythmic drug therapy in paroxysmal atrial fibrillation (AF) randomized controlled trial M Objective: To compare the relative efficacy of circumferential pulmonary vein ablation (CPVA) & antiarrhythmic drug therapy (ADT) in the treatment of patients with paroxysmal atrial fibrillation (PAF) who have already […]
ANTLER Trial: Antidepressants in Primary care
2021 ANTLER TRIAL Maintenance or discontinuation of antidepressants in primary care Multicenter, randomized, double-blind trial M Objective: To assess the effects of maintenance antidepressant therapy, as compared with discontinuation of treatment, in patients taking antidepressants 478 patients Inclusion criteria: Participants 18 to 74 years of age with >2 prior episodes of depression or took […]
ANTHARTIC Trial: Preventing VAP after CA
2019 ANTHARTIC TRIAL M Prevention of early Ventilator-Associated Pneumonia after cardiac arrest Multicentre, randomised, double-blind, placebo-controlled Objective: To investigate whether in post out-of-hospital cardiac arrest (OOHCA) patients treated with targeted temperature management, does the use of empirical antibiotics prevent early ventilator-associated pneumonia. 194 patients Inclusion criteria: Patients ≥ 18 years of age hospitalized in the […]