AF-CHF: Rhythm Control versus Rate Control for Atrial Fibrillation and Heart Failure Multicenter, prospective, randomized, controlled trial Objective: To assess if rhythm-control reduce CV mortality in patients with AF and HFrEF as compared to rate control. Patients with AF and … Read More
Cardiovascular Disease
ACT Trial Summary: Acetylcysteine before Angiography
ACETYLCYSTEINE FOR PREVENTION OF RENAL OUTCOMES IN PATIENTS UNDERGOING ANGIOGRAPHY – ACT TRIAL Multicenter, Double-blind, Randomized, Placebo-controlled Trial STUDY OBJECTIVE: To Assess the use of acetylcysteine for preventing contrast-induced acute kidney injury in patients undergoing angiography 2308 Adults with ≥1 … Read More
ADAM VTE Trial Summary: Apixaban in Cancer-associated VTE
2019 ADAM VTE TRIAL Apixaban and dalteparin in active malignancy-associated venous thromboembolism multicenter, randomized, open-label superiority trial 287 patients 0 Objective: To study side effects of and compare apixaban and dalteparin in reducing blood clots in patients with cancer-related VTE. … Read More
ADAPTABLE Trial Summary: Aspirin Dosing in CV Disease
2013 ADAPTABLE TRIAL Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease Open-label, pragmatic design, randomized controlled trial M Objective: To assess whether a strategy of aspirin 325 mg/day would result in a lower risk of death from any cause, hospitalization … Read More
ACTIVE W Trial Summary: Clopidogrel + ASA vs. OAC for Atrial Fibrillation
2006 ACTIVE W TRIAL Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation Randomized, open treatment, controlled trial M Objective: Among patients with nonvalvular AF, how does combination aspirin/clopidogrel compare to warfarin in reducing the incidence of stroke, systemic embolism, … Read More
ACTIVE A Trial Summary: Clopidogrel + Aspirin in Atrial Fibrillation
2009 ACTIVE A TRIAL Effect of Clopidogrel Added to Aspirin in Patients with Atrial Fibrillation Multicenter, double-blind, parallel-group trial M Objective: To assess if the addition of clopidogrel to aspirin reduces the risk of vascular events compared to aspirin alone … Read More
ISAR-SAFE Trial Summary: 6 vs 12 months of DAPT after DES PCI
2015 ISAR-SAFE TRIAL M A randomized, double-blind, placebo-controlled trial of 6 vs. 12 months of clopidogrel therapy after drug-eluting stenting multicentre, double-blind, placebo-controlled, randomized controlled trial Objective: To compare the clinical outcome of 6 months of clopidogrel therapy to 12 … Read More
LOOP Trial: ILR for AFib to Prevent Stroke
2021 LOOP TRIAL Implantable loop recorder detection of atrial fibrillation to prevent stroke open-label, randomized controlled trial Objective: To assess the efficacy and safety of continuous monitoring for atrial fibrillation (AF) with an implantable loop recorder (ILR) versus usual care … Read More
NAPLES III Trial Summary: Bivalirudin in Patients with High Risk of Bleeding Undergoing LHC
2015 NAPLES III TRIAL Randomized comparison of bivalirudin versus unfractionated heparin in patients at increased risk of bleeding undergoing transfemoral elective coronary stenting double-blind, single-center, randomized controlled trial Objective: To assess the safety & the efficacy of bivalirudin compared with … Read More
ODYSSEY COMBO II Trial Summary: Alirocumab in High CV risk Patients with Hypercholesterolemia
2015 ODYSSEY COMBO II TRIAL Efficacy and safety of alirocumab in high cardiovascular risk patients with inadequately controlled hypercholesterolaemia double-blind, double-dummy, placebo controlled, parallel, randomized controlled trial Objective: To assess the efficacy & safety of alirocumab compared with therapy to … Read More