The HEART-FID trial, as published in the New England Journal of Medicine in 2023, was a randomized, double-blind, placebo-controlled study designed to determine the efficacy and safety of intravenous ferric carboxymaltose (FCM) in treating patients with heart failure with reduced … Read More
Cardiovascular Disease
FIRE Trial: Complete PCI in MI in Older Patients
The FIRE trial, published in the New England Journal of Medicine in 2023, was a multicenter, randomized controlled trial that aimed to evaluate the benefits of complete revascularization versus culprit-lesion-only percutaneous coronary intervention (PCI) in older patients (≥75 years of … Read More
ECLS-SHOCK Trial: Extracorporeal Life Support in Cardiogenic Shock
The ECLS-SHOCK trial, as reported in the New England Journal of Medicine in 2023, was a multicenter, parallel, randomized controlled trial designed to evaluate the efficacy of extracorporeal life support (ECLS) in patients with acute myocardial infarction (MI) complicated by … Read More
RADIANCE-HTN TRIO Trial: Renal Denervation in HTN
The RADIANCE-HTN TRIO trial, detailed in The Lancet in 2021, is another pivotal study in the domain of hypertension treatment, focusing on a challenging group of patients: those resistant to a standard triple combination pill. This trial delves into the … Read More
SELECT Trial: Semaglutide and CV outcomes
Semaglutide Improve CV events? SELECT Trial Summary The SELECT trial, a pivotal study published in the New England Journal of Medicine (NEJM) in November 2023, has offered the medical community valuable insights into the treatment of cardiovascular (CV) events in … Read More
ORBITA-2 Trial: PCI in Stable Angina
Understanding the Impact of PCI in Stable Angina: Insights from the ORBITA-2 Trial The ORBITA-2 trial has emerged as a cornerstone study in the field of cardiology, particularly in the treatment of stable angina through Percutaneous Coronary Intervention (PCI). This … Read More
T-PASS Trial: A Shift in Post-Stenting Treatment for ACS
T-PASS Trial Summary The management of Acute Coronary Syndrome (ACS) after stenting has been a hot topic for medical researchers for years. The recent T-PASS Trial in 2023 has shed light on the possible advantages of shifting from the conventional … Read More
RITA 3 Trial: Interventional vs. Conservative Strategy in UA/NSTEMI
RITA 3 Trial Summary Background: Methods: Findings: Interpretation: Key Takeaways: Source
ELAN Trial: Early vs. Later Initiation of DOAC in Acute Ischemic Stroke and Atrial Fibrillation
ELAN Trial Summary Introduction:The ELAN trial aimed to investigate the optimal timing of initiating direct oral anticoagulants (DOACs) in individuals with atrial fibrillation (AF) who had experienced an acute ischemic stroke. The study compared early anticoagulation (initiated within 48 hours … Read More
DIGAMI 2 Trial: Insulin-Based Glucose Control in Type 2 Diabetic Patients Following MI
DIGAMI 2 Trial Summary Introduction:The DIGAMI 2 trial aimed to evaluate the effect of insulin-based glucose control in type 2 diabetic patients following myocardial infarction compared to conventional management at similar levels of glucose control. The study investigated three treatment … Read More