Category: Cardiovascular Disease

AMPLIFY Trial: Apixaban for acute VTE

2013 AMPLIFY TRIAL Oral Apixaban for the Treatment of Acute Venous Thromboembolism double-blind, multicenter, randomized controlled trial IM Objective: To determine if apixaban is non-inferior to conventional therapy with LMWH in patients with pulmonary embolism or proximal deep venous thrombosis Inclusion criteria: Patients ≥18 years with symptomatic VTE, 5,395 either DVT proximal to popliteal vein […]

Wolf-Parkinson-White (WPW) Syndrome: Infographic

Wolff-Parkinson-White (WPW) Syndrome Characterized by presence of accessory pathway (bundle of Kent) between atria and ventricle that can cause “preexcitation” or earlier activation of the His-Purkinje system. ECG Features Delta wave: slow muscle- fiber-to-muscle-fiber conduction WPW pattern: Preexcitation pattern on ECG without symptomatic arrhythmias WPW Syndrome: ECG findings + arrhythmias Pathway Associated Arrhythmia Atrioventricular reentrant […]

ISCHEMIA Trial: Invasive or Medical therapy for Stable CAD

2020 ISCHEMIA TRIAL M Initial Invasive or Conservative Strategy for Stable Coronary Disease multicenter, parallel, randomized controlled trial Objective: Tto determine the effect of adding cardiac catheterization (hereafter, angiography) and revascularization when feasible to medical therapy in patients with stable coronary disease and moderate or severe ischemia 5,179 Patients Inclusion criteria: Patients >20 years of […]

ACUTE Trial Summary: TEE-Guided Cardioversion for AFib

2001 ACUTE TRIAL Use of transesophageal echocardiography to guide cardioversion in patients with atrial fibrillation multicenter, prospective, randomized controlled trial Objective: To compare conventional anticoagulation strategy with the transesophageal echocardiography to guide short-term anticoagulant therapy in patients with atrial fibrillation prescribed with electrical cardioversion 1222 patients Inclusion criteria: Patients aged ≥18 years who had atrial […]

BRIGHT-4 Trial Summary: Bivalirudin in STEMI

2022 BRIGHT-4 TRIAL Bivalirudin plus a high-dose infusion versus heparin monotherapy in patients with STEMI undergoing primary PCI investigator-initiated, open-label, randomized controlled trial Objective: To evaluate the safety and efficacy of a high-dose infusion of bivalirudin after primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) compared with unfractionated heparin 6016 […]

CANARY Trial Summary: Cath vs AC in PE

2022 CANARY TRIAL Catheter-directed thrombolysis vs anticoagulation in patients with acute intermediate-high-risk pulmonary embolism parallel, open-label, randomized controlled trial Objective: To assess the effectiveness of catheter-directed thrombolysis (CCDT) compared with anticoagulation among intermediate- to high-risk individuals with acute pulmonary embolism 94 patients Inclusion criteria: Patients ≥18 years with acute pulmonary embolism presenting within 14 days […]

CATCH Trial Summary: Tinzaparin for VTE in Cancer

2015 CATCH TRIAL Tinzaparin vs warfarin for treatment of acute venous thromboembolism in patients with active cancer phase 3, multinational, open-label, randomized controlled trial Objective: To assess the efficacy and safety of tinzaparin vs warfarin for treatment of acute, symptomatic venous thromboembolism (VTE) in patients with active cancer 900 Patients Inclusion criteria: Patients ≥ 18 […]

COACH Trial Summary: Access to Care in Heart Failure

2022 COACH TRIAL Trial of an intervention to improve acute heart failure outcomes cross-sectional, cluster-randomized trial M Objective: To determine the effectiveness of systematic use of a hospital-based point-of-care tool to support clinical decision-making, followed by rapid follow-up in an outpatient clinic among patients with acute heart failure seeking emergency care 5452 patients Inclusion criteria: […]

DCP Trial Summary: HCTZ vs Chlorthalidone

2022 DCP TRIAL Chlorthalidone compared with hydrochlorothiazide for the preven- tion of cardiovascular events in patients with hypertension: The Diuretic Comparison Project (DCP) Open-label, pragmatic, randomized controlled trial Objective: To compare the differences between hydrochlorothiazide (HCTZ) compared with chlorthalidone in improving cardiovascular outcomes among patients with hypertension 13523 patients Inclusion criteria: Patients >65 years on […]

UNIVERSAL Trial Summary: US-Guided Femoral Access

2022 UNIVERSAL TRIAL Routine ultrasonography guidance for femoral vascular access for cardiac procedures multicenter, randomized controlled trial Objective: To determine whether routinely using ultrasonography guidance for femoral arterial access for coronary angiography/intervention reduces bleeding or vascular complications 621 Patients Inclusion criteria: Patients ≥18 years with referral for coronary angiography or percutaneous coronary intervention with planned […]