WOSCOPS Trial Summary “The WOSCOPS Trial: Pravastatin’s Role in Reducing the Incidence of Myocardial Infarction and Death from Cardiovascular Causes” The West of Scotland Coronary Prevention Study (WOSCOPS) has significantly contributed to our understanding of the role of pravastatin in … Read More
Cardiovascular Disease
WRAP-IT Trial: Utilizing Antibiotic-Eluting Envelopes to Reduce Infections After Cardiac Device Implantation
WRAP-IT Trial Summary Infections following the placement of cardiac implantable electronic devices (CIEDs) can lead to significant morbidity and mortality. Although preoperative antibiotics are a standard prophylactic strategy, evidence for other preventive approaches is limited. The WRAP-IT trial sought to … Read More
PROMINENT Trial: Evaluating the Efficacy of Pemafibrate in Reducing Cardiovascular Events
High levels of triglycerides, a type of fat found in the blood, have been connected to an increased risk of cardiovascular diseases. The question of whether decreasing these levels can reduce the incidence of cardiovascular events has been under investigation. … Read More
A New Frontier in Heart Failure Management: A Comprehensive Review of Landmark Clinical Trials on SGLT2 Inhibitors
Explore the transformative clinical trials that have solidified the role of SGLT2 inhibitors in heart failure management and their potential to redefine the treatment landscape. Introduction Heart failure is a complex clinical syndrome associated with significant morbidity and mortality. In … Read More
Navigating the New Era: Landmark Clinical Trials on Eliquis (Apixaban) for Anticoagulation in Atrial Fibrillation
Atrial fibrillation (AFib) is a prevalent cardiac arrhythmia that significantly elevates the risk of stroke and systemic embolism. As a result, effective anticoagulation therapy is crucial for managing AFib patients. Over the past decade, novel oral anticoagulants (NOACs) have challenged … Read More
Pioneering the Path: Key Landmark Trials on Ablation Procedures for Atrial Fibrillation
Delve into the pivotal clinical trials that have shaped our understanding and management of atrial fibrillation through ablation procedures. … Read More
The Data Behind HFpEF Management: Landmark Clinical Trials on Heart Failure with Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) is a complex and increasingly prevalent form of heart failure, accounting for nearly half of all heart failure cases. Despite its significance, HFpEF remains a challenging condition to manage and treat, as effective … Read More
APAF Trial: Ablation or Antiarrhythmics for PAF
2006 APAF STUDY A randomized trial of circumferential pulmonary vein ablation versus antiarrhythmic drug therapy in paroxysmal atrial fibrillation (AF) randomized controlled trial M Objective: To compare the relative efficacy of circumferential pulmonary vein ablation (CPVA) & antiarrhythmic drug … Read More
ANTHARTIC Trial: Preventing VAP after CA
2019 ANTHARTIC TRIAL M Prevention of early Ventilator-Associated Pneumonia after cardiac arrest Multicentre, randomised, double-blind, placebo-controlled Objective: To investigate whether in post out-of-hospital cardiac arrest (OOHCA) patients treated with targeted temperature management, does the use of empirical antibiotics prevent early … Read More
ANT 005 TKA Trial: Abelacimab for VTE
2021 ANT-005 TKA TRIAL M Abelacimab for Prevention of Venous Thromboembolism (VTE) Phase 2,open-label, prospective randomized trial 400 Objective: To compare the efficacy & safety of abelacimab administered postoperatively with the efficacy & safety of enoxaparin in patients undergoing … Read More