2009 ACTIVE A TRIAL Effect of Clopidogrel Added to Aspirin in Patients with Atrial Fibrillation Multicenter, double-blind, parallel-group trial M Objective: To assess if the addition of clopidogrel to aspirin reduces the risk of vascular events compared to aspirin alone … Read More
Cardiovascular Disease
ISAR-SAFE Trial Summary: 6 vs 12 months of DAPT after DES PCI
2015 ISAR-SAFE TRIAL M A randomized, double-blind, placebo-controlled trial of 6 vs. 12 months of clopidogrel therapy after drug-eluting stenting multicentre, double-blind, placebo-controlled, randomized controlled trial Objective: To compare the clinical outcome of 6 months of clopidogrel therapy to 12 … Read More
LOOP Trial: ILR for AFib to Prevent Stroke
2021 LOOP TRIAL Implantable loop recorder detection of atrial fibrillation to prevent stroke open-label, randomized controlled trial Objective: To assess the efficacy and safety of continuous monitoring for atrial fibrillation (AF) with an implantable loop recorder (ILR) versus usual care … Read More
NAPLES III Trial Summary: Bivalirudin in Patients with High Risk of Bleeding Undergoing LHC
2015 NAPLES III TRIAL Randomized comparison of bivalirudin versus unfractionated heparin in patients at increased risk of bleeding undergoing transfemoral elective coronary stenting double-blind, single-center, randomized controlled trial Objective: To assess the safety & the efficacy of bivalirudin compared with … Read More
ODYSSEY COMBO II Trial Summary: Alirocumab in High CV risk Patients with Hypercholesterolemia
2015 ODYSSEY COMBO II TRIAL Efficacy and safety of alirocumab in high cardiovascular risk patients with inadequately controlled hypercholesterolaemia double-blind, double-dummy, placebo controlled, parallel, randomized controlled trial Objective: To assess the efficacy & safety of alirocumab compared with therapy to … Read More
PADN-CFDA Trial Summary: PA Denervation for PAH
2022 PADN-CFDA TRIAL Pulmonary artery denervation for pulmonary arterial hypertension (PAH) multicenter, sham-controlled single-blind, randomized controlled trial Objective: To evaluate the treatment effects of pulmonary artery denervation (PADN) among patients with Group I PAH who were not on PAH-specific drugs … Read More
PERSPECTIVE Trial Summary: Sacubitril/valsartan Effect on Cognition in HFpEF
2022 PERSPECTIVE TRIAL M Efficacy and safety of sacubitril/valsartan compared to valsartan on cognitive function in patients with chronic heart failure and preserved ejection fraction parallel, randomized controlled trial Objective: To evaluate the effectiveness of sacubitril/valsartan compared with valsartan alone … Read More
POPular AGE Trial Summary: Antiplatelet agent in NSTEMI
2020 POPULAR AGE TRIAL Clopidogrel versus ticagrelor or prasugrel in patients aged 70 years or older with non-ST-elevation acute coronary syndrome multicenter, randomized controlled trial Objective: To evaluate the effectiveness of clopidogrel compared with ticagrelor or prasugrel among patients ≥70 … Read More
A-HEFT Trial Summary: Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure
2004 -0.1 3.1 A-HEFT TRIAL Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure Inclusion criteria: patients self-identified as 1,050 black (of African descent) with NYHA class III-IV patients HF ≥3 months on standard therapy, including ACEI/ARBs, ẞ-blockers, … Read More
AATAC Trial Summary: Ablation vs. amiodarone for Persistent Atrial Fibrillation
2016 AATAC TRIAL Ablation vs. amiodarone for treatment of persistent atrial fibrillation in CHF Multicenter, parallel-group, open-label, randomized Objective: To assess if AF ablation is superior to y amiodarone in patients with symptomatic (NYHA II-III) heart failure with reduced ejection … Read More