2017 2017 TRICOP TRIAL Liberal vs restrictive transfusion strategy in critically ill oncologic patients: The transfusion requirements in critically ill oncologic Single-center, randomized, double-blind controlled trial Objective: To assess whether a restrictive strategy of RBC transfusion reduces 28-day mortality when … Read More
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WOMAN Trail Summary: Early tranexamic acid in post-partum hemorrhage
2018 WOMAN TRIAL Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage Randomised, double-blind, placebo-controlled trial Objective: To determine whether early administration of tranexamic acid reduces death from bleeding in women with … Read More
VITAL Trial: Vitamin D and Incident Fractures
2022 VITAL TRIAL Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults double-blind, placebo-controlled, 2×2 factorial, randomized controlled trial Objective: To investigate the effects of supplemental vitamin D3 as compared with placebo on incident fractures among generally healthy … Read More
VISION Trial Summary: Lutetium 177 PSMA 617 for Metastatic Prostate Cancer
2021 VISION TRIAL Lutetium-177-PSMA-617 for metastatic castration-resistant prostate cancer Prospective, open-label, randomized, international, phase 3 trial Objective: To evaluate Lutetium-177 (177Lu)-PSMA-617 a radioligand therapy along with standard care in Prostate-specific membrane antigen (PSMA) positive metastatic castration-resistant prostate cancer as compared … Read More
SECURE Trial Summary: Polypill Strategy in Secondary Cardiovascular Prevention
2022 SECURE TRIAL Polypill Strategy in Secondary Cardiovascular Prevention Phase 3, randomized, controlled clinical trial Objective: To evaluate the effect of polypill that includes key medications (aspirin, ramipril, and atorvastatin) on cardiovascular events in post-Ml patients. 2499 Inclusion criteria: Patients … Read More
TTM 48 Trial Summary: TTM for 48 hours in Cardiac Arrest
2017 2017 TTM 48 TRIAL M Targeted Temperature Management for 48 vs 24 hours and neurologic outcome after out-of-Hospital Cardiac Arrest (OOHCA) Multicenter,blinded,parallel,pragmatic,randomized superiority trial Objective: To determine neurologic outcomes with Targeted Temperature Management (TTM) at 33°C for 48 hours … Read More
REDECAP Trial Summary: High-Flow Oxygen for Tracheostomy Decannulation
2020 REDECAP TRIAL M High-flow oxygen with capping or suctioning for tracheostomy decannulation Multicentre randomised controlled trial So Objective: To compare an assessment of readiness for decannulation that is based on suctioning frequency with an assessment based on tracheostomy capping … Read More
ATESS Trial Summary: Vitamin C + Thiamine for Septic Shock
2020 ATESS TRIAL Combination therapy of vitamin C and thiamine for septic shock Multicentre, double-blind, randomized controlled trial Objective: To evaluate the effects of early combination therapy with intravenous vitamin C and thiamine on recovery from organ failure in patients … Read More
PSP Trial Summary: Interventional Treatment for Spontaneous Pneumothorax
2020 PSP TRIAL M Conservative versus interventional treatment for spontaneous pneumothorax Prospective, randomized control, non-inferiority trial Objective: To assess whether conservative management compared to interventional treatment results in acceptable rates of lung re-expansion at 8 weeks in patients with primary … Read More
FIESTY Trial Summary: Fibrinogen in Severe Trauma
2021 FEISTY TRIAL Fibrinogen early in severe trauma study | multicentre, randomized controlled pilot study s Objective: To compare the time to fibrinogen replacement using f ibrinogen concentrate (FC) or cryoprecipitate (Cryo) in severely injured trauma patients with major hemorrhage … Read More