2013 SINGLE TRIAL M Dolutegravir plus abacavir-lamivudine for the treatment of HIV-1 infection double-blind, randomized controlled trial 844 Objective: To assess the safety & efficacy of dolutegravir at a dose of 50 mg plus a fixed-dose combination of abacavir-lamivudine, as … Read More
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BEHoLD Trial: Entecavir + Lamivudine for Hep B
2006 BEHOLD TRIAL A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B multicenter, double-blind, double-dummy, randomized controlled trial M Objective: To compare the efficacy and safety of 48 weeks of therapy with entecavir with 48 weeks of therapy … Read More
BASICS Trial: Endovascular Therapy for Basilar Stroke
2021 BASICS TRIAL Endovascular therapy for stroke due to basilar-artery occlusion multicenter, open-label, randomized controlled trial M Objective: To determine effectiveness of endovascular therapy in patients with stroke caused by basilar-artery occlusion. 300 patients. Inclusion criteria: Patients aged ≥ 18 … Read More
MADIT-CRT Trial Summary: CRT in HF
2009 MADIT-CRT TRIAL Cardiac-Resynchronization Therapy for the prevention of heart-failure events multicenter, open-label, randomized controlled trial Objective: To determine whether cardiac-resynchronization therapy with implantable cardioverter-defibrillator (CRT-ICD) would reduce the risk of death or heart-failure events in M patients with mild … Read More
ACUTE Trial Summary: TEE-Guided Cardioversion for AFib
2001 ACUTE TRIAL Use of transesophageal echocardiography to guide cardioversion in patients with atrial fibrillation multicenter, prospective, randomized controlled trial Objective: To compare conventional anticoagulation strategy with the transesophageal echocardiography to guide short-term anticoagulant therapy in patients with atrial fibrillation … Read More
BRIGHT-4 Trial Summary: Bivalirudin in STEMI
2022 BRIGHT-4 TRIAL Bivalirudin plus a high-dose infusion versus heparin monotherapy in patients with STEMI undergoing primary PCI investigator-initiated, open-label, randomized controlled trial Objective: To evaluate the safety and efficacy of a high-dose infusion of bivalirudin after primary percutaneous coronary … Read More
CANARY Trial Summary: Cath vs AC in PE
2022 CANARY TRIAL Catheter-directed thrombolysis vs anticoagulation in patients with acute intermediate-high-risk pulmonary embolism parallel, open-label, randomized controlled trial Objective: To assess the effectiveness of catheter-directed thrombolysis (CCDT) compared with anticoagulation among intermediate- to high-risk individuals with acute pulmonary embolism … Read More
CATCH Trial Summary: Tinzaparin for VTE in Cancer
2015 CATCH TRIAL Tinzaparin vs warfarin for treatment of acute venous thromboembolism in patients with active cancer phase 3, multinational, open-label, randomized controlled trial Objective: To assess the efficacy and safety of tinzaparin vs warfarin for treatment of acute, symptomatic … Read More
COACH Trial Summary: Access to Care in Heart Failure
2022 COACH TRIAL Trial of an intervention to improve acute heart failure outcomes cross-sectional, cluster-randomized trial M Objective: To determine the effectiveness of systematic use of a hospital-based point-of-care tool to support clinical decision-making, followed by rapid follow-up in an … Read More
DCP Trial Summary: HCTZ vs Chlorthalidone
2022 DCP TRIAL Chlorthalidone compared with hydrochlorothiazide for the preven- tion of cardiovascular events in patients with hypertension: The Diuretic Comparison Project (DCP) Open-label, pragmatic, randomized controlled trial Objective: To compare the differences between hydrochlorothiazide (HCTZ) compared with chlorthalidone in … Read More