2015 ODYSSEY COMBO II TRIAL Efficacy and safety of alirocumab in high cardiovascular risk patients with inadequately controlled hypercholesterolaemia double-blind, double-dummy, placebo controlled, parallel, randomized controlled trial Objective: To assess the efficacy & safety of alirocumab compared with therapy to … Read More
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PADN-CFDA Trial Summary: PA Denervation for PAH
2022 PADN-CFDA TRIAL Pulmonary artery denervation for pulmonary arterial hypertension (PAH) multicenter, sham-controlled single-blind, randomized controlled trial Objective: To evaluate the treatment effects of pulmonary artery denervation (PADN) among patients with Group I PAH who were not on PAH-specific drugs … Read More
PERSPECTIVE Trial Summary: Sacubitril/valsartan Effect on Cognition in HFpEF
2022 PERSPECTIVE TRIAL M Efficacy and safety of sacubitril/valsartan compared to valsartan on cognitive function in patients with chronic heart failure and preserved ejection fraction parallel, randomized controlled trial Objective: To evaluate the effectiveness of sacubitril/valsartan compared with valsartan alone … Read More
POPular AGE Trial Summary: Antiplatelet agent in NSTEMI
2020 POPULAR AGE TRIAL Clopidogrel versus ticagrelor or prasugrel in patients aged 70 years or older with non-ST-elevation acute coronary syndrome multicenter, randomized controlled trial Objective: To evaluate the effectiveness of clopidogrel compared with ticagrelor or prasugrel among patients ≥70 … Read More
POPULAR CABG Trial Summary: Ticagrelor in CABG
2020 POPULAR CABG TRIAL Effect of adding ticagrelor to standard aspirin on saphenous vein graft (SVG) patency in patients undergoing coronary artery bypass grafting double-blind, placebo-controlled, multicenter, randomized controlled trial M Objective: To assess whether ticagrelor added to standard aspirin … Read More
ICEREA Trial Summary: Endovascular Versus External TTM in Cardiac Arrest
2015 ICEREA TRIAL Endovascular versus external targeted temperature management for patients with out-of-hospital cardiac arrest multicenter, prospective, randomized controlled trial Objective: To evaluate if endovascular cooling is superior to external targeted temperature management in regards to favorable outcome after out-of-hospital … Read More
65 Trial Summary: Vasopressors in Older Critically Ill Patients
2020 65 TRIAL Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Critically III patients Multicenter, pragmatic, randomized clinical trial Objective: To evaluate the effect on mortality at 90 days of reducing the exposure to vasopressors through permissive hypotension … Read More
A-HEFT Trial Summary: Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure
2004 -0.1 3.1 A-HEFT TRIAL Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure Inclusion criteria: patients self-identified as 1,050 black (of African descent) with NYHA class III-IV patients HF ≥3 months on standard therapy, including ACEI/ARBs, ẞ-blockers, … Read More
AATAC Trial Summary: Ablation vs. amiodarone for Persistent Atrial Fibrillation
2016 AATAC TRIAL Ablation vs. amiodarone for treatment of persistent atrial fibrillation in CHF Multicenter, parallel-group, open-label, randomized Objective: To assess if AF ablation is superior to y amiodarone in patients with symptomatic (NYHA II-III) heart failure with reduced ejection … Read More
ACCOMPLISH Trial: Benazepril + Amlodipine or HCTZ for Hypertension
2008 ACCOMPLISH TRIAL Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension in High-Risk Patients Multi-centered, double-blind, randomized, controlled trial Objective: To evaluate the effect of amlodipine vs. hydrochlorothiazide in patients with hypertension and at high risk for cardiovascular disease. E 11,506 … Read More