LIXIPARK Trial: Lixisenatide in Early Parkinson’s Disease

Objective: To evaluate the effect of lixisenatide, versus placebo, administered as add-on therapy with the usual antiparkinsonian treatment, on the progression of motor disability in patients with early Parkinson’s Disease (PD) to assess its potential “disease-modifying” effect. Inclusion Criteria: Exclusion … Read More

RESCUE BT2 Trial: Tirofiban for Acute Ischemic Stroke

Summary of the RESCUE BT2 Trial: Tirofiban in Acute Ischemic Stroke Background: Methods: Inclusion criteria: Results: Conclusions: Key Takeaways: Source

INTERACT3 Trial: ICU care bundle in acute ICH

INTERACT3 Trial Summary Background: Methods: Findings: Primary Outcome: Interpretation: Trial Information: Key Takeaways: Source

WAKE-UP Trial: MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset

WAKE-UP Trial Summary The WAKE-UP trial aimed to investigate the potential benefits of intravenous alteplase, a thrombolytic agent, in treating acute stroke patients with an unknown time of onset. Current guidelines recommend intravenous thrombolysis only if the time since symptom … Read More

BASICS Trial: Endovascular Therapy for Basilar Stroke

2021 BASICS TRIAL Endovascular therapy for stroke due to basilar-artery occlusion multicenter, open-label, randomized controlled trial M Objective: To determine effectiveness of endovascular therapy in patients with stroke caused by basilar-artery occlusion. 300 patients. Inclusion criteria: Patients aged ≥ 18 … Read More

LOOP Trial: ILR for AFib to Prevent Stroke

2021 LOOP TRIAL Implantable loop recorder detection of atrial fibrillation to prevent stroke open-label, randomized controlled trial Objective: To assess the efficacy and safety of continuous monitoring for atrial fibrillation (AF) with an implantable loop recorder (ILR) versus usual care … Read More

TICH-2 Trial Summary: Tranexamic acid for IntraCerebral Haemorrhage

2018 TICH-2 TRIAL Tranexamic acid for hyperacute primary intracerebral haemorrhage Double blind, randomised, placebo-controlled, phase 3 superiority trial Objective: To assess whether tranexamic acid reduces haematoma expansion and improves outcome in adults with stroke due to intracerebral haemorrhage 3 2325 … Read More

MR CLEAN-NO IV Trial Summary: IV Alteplase before Endovascular Therapy in Stroke

2021 MR CLEAN-NO IV TRIAL M 2021 A Randomized Trial of Intravenous Alteplase before Endovascular Treatment(EVT) for Stroke investigator-initiated, international, multicenter, prospective, randomized, open-label trial ” d Objective: To determine whether EVT alone would be more effective, or noninferior, as … Read More

ESETT Trial Summary: Anticonvulsant Medications for Status Epilepticus

2019 ESETT TRIAL Randomized trial of three anticonvulsant medications for Status Epilepticus Investigator-initiated, blinded, randomized controlled trial Objective: To investigate whether in patients with status epilepticus who have been treated with benzodiazepines, is Levetriracetam, Valproate or Fosphenyoin more likely to … Read More

DIRECT MT Trial Summary: Thrombectomy with or without Alteplase in Stroke

2020 DIRECT-MT TRIAL: Endovascular thrombectomy with or without intravenous alteplase in acute stroke Investigator-initiated, multicentre, prospective, randomised, open-label trial Objective: To evaluate endovascular thrombectomy with or without intravenous alteplase in patients with acute ischemic stroke 656 patients Participants > 18 … Read More