Category: Neurology

WAKE-UP Trial: MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset

WAKE-UP Trial Summary The WAKE-UP trial aimed to investigate the potential benefits of intravenous alteplase, a thrombolytic agent, in treating acute stroke patients with an unknown time of onset. Current guidelines recommend intravenous thrombolysis only if the time since symptom onset is less than 4.5 hours. However, the trial sought to determine whether patients with […]

BASICS Trial: Endovascular Therapy for Basilar Stroke

2021 BASICS TRIAL Endovascular therapy for stroke due to basilar-artery occlusion multicenter, open-label, randomized controlled trial M Objective: To determine effectiveness of endovascular therapy in patients with stroke caused by basilar-artery occlusion. 300 patients. Inclusion criteria: Patients aged ≥ 18 years with symptoms and signs compatible with ischemia in the basilar artery territory مجھے Endovascular […]

LOOP Trial: ILR for AFib to Prevent Stroke

2021 LOOP TRIAL Implantable loop recorder detection of atrial fibrillation to prevent stroke open-label, randomized controlled trial Objective: To assess the efficacy and safety of continuous monitoring for atrial fibrillation (AF) with an implantable loop recorder (ILR) versus usual care among patients at high risk for stroke without known history of AF 6004 Patients Inclusion […]

TICH-2 Trial Summary: Tranexamic acid for IntraCerebral Haemorrhage

2018 TICH-2 TRIAL Tranexamic acid for hyperacute primary intracerebral haemorrhage Double blind, randomised, placebo-controlled, phase 3 superiority trial Objective: To assess whether tranexamic acid reduces haematoma expansion and improves outcome in adults with stroke due to intracerebral haemorrhage 3 2325 Inclusion criteria: Adult patients with Intracerebral haemorrhage admitted to hospital within 8 hours of stroke […]

MR CLEAN-NO IV Trial Summary: IV Alteplase before Endovascular Therapy in Stroke

2021 MR CLEAN-NO IV TRIAL M 2021 A Randomized Trial of Intravenous Alteplase before Endovascular Treatment(EVT) for Stroke investigator-initiated, international, multicenter, prospective, randomized, open-label trial ” d Objective: To determine whether EVT alone would be more effective, or noninferior, as compared with intravenous alteplase followed by EVT in European patients with acute ischemic stroke due […]

ESETT Trial Summary: Anticonvulsant Medications for Status Epilepticus

2019 ESETT TRIAL Randomized trial of three anticonvulsant medications for Status Epilepticus Investigator-initiated, blinded, randomized controlled trial Objective: To investigate whether in patients with status epilepticus who have been treated with benzodiazepines, is Levetriracetam, Valproate or Fosphenyoin more likely to lead to an absence of seizures and improved responsiveness at 60 minutes 384 patients Patients […]

DIRECT MT Trial Summary: Thrombectomy with or without Alteplase in Stroke

2020 DIRECT-MT TRIAL: Endovascular thrombectomy with or without intravenous alteplase in acute stroke Investigator-initiated, multicentre, prospective, randomised, open-label trial Objective: To evaluate endovascular thrombectomy with or without intravenous alteplase in patients with acute ischemic stroke 656 patients Participants > 18 years with occlusion of the intracranial segment of the ICA and/or of the 1st or […]