Tag: critically ill

PLUS Trial Summary: Balanced Multielectrolyte Solution in Critically Ill

2022 PLUS TRIAL Balanced multi electrolyte solution versus saline in critically ill adults Investigator initiated, double-blind, parallel-group, randomised controlled trial d a Objective: To assess whether the use of balanced multielectrolyte solution (BMES) in preference to 0.9% sodium chloride solution (saline) in critically ill patients reduces the risk of acute kidney injury or death 5037 […]

TRICOP Trial Summary: Transfusion strategy in critically ill Oncologic patients

2017 2017 TRICOP TRIAL Liberal vs restrictive transfusion strategy in critically ill oncologic patients: The transfusion requirements in critically ill oncologic Single-center, randomized, double-blind controlled trial Objective: To assess whether a restrictive strategy of RBC transfusion reduces 28-day mortality when compared with a liberal strategy in cancer patients with septic shock. E 157 Inclusion criteria: […]

LOCO2 Trial Summary: Oxygen Therapy in ARDS

2020 2020 LOCO2 TRIAL M Liberal or conservative oxygen therapy for Acute Respiratory Distress Syndrome Multicentre, randomised controlled trial Objective: To assess whether in patients with Acute Respiratory Distress Syndrome (ARDS), does conservative (Target PaO2:55-70mmHg; SpO2: 88-92%) vs. liberal (Target PaO2:90-105mmHg; SpO2: 96%) oxygen reduce death at 28 days 201 patients Adults who were intubated […]

NONSEDA Trial Summary: Sedation in Critically Ill Intubated Patients

2020 NONSEDA TRIAL M Nonsedation or light sedation in critically ill, mechanically ventilated patients Investigator-initiated, randomised, clinical, parallel-group, multinational, superiority trial . a 5 Objective: To assess whether in critically ill, mechanically ventilated patients, does a strategy of no sedation, as compared with light sedation with daily sedation breaks, impact day 90 mortality. 192 patients […]

CHECK-UP Trial Summary: Ramped vs Sniffing Position for Intubation

2017 CHECK-UP: POSITION- Ramped position vs Sniffing position during endotracheal intubation of critically ill adults 2 x 2 factorial design,randomised, multicentre,pragmatic trial 9 5 Objective: To evaluate the reduction in incidence of oxygen desaturation in ramped position as compared to sniffing position in emergency intubation in critically ill ICU patients 260 patients Patients >18 yrs […]

EAT-ICU Trial Summary: Early Goal-Directed Nutrition in ICU Patients

2017 EAT-ICU TRIAL: Early goal-directed nutrition versus standard of care in adult intensive care patients Single centre, blinded, randomised controlled trial Objective: To evaluate the effects of early goal-directed nutrition (EGDN) vs. standard nutritional care in adult ICU patients. 203 Inclusion criteria: Acutely ICU admitted, mechanically ventilated patients, aged >18 yrs with a central venous […]

EPICC Trial Summary: Intensive Physical Rehabilitation in Critically ill

2017 EPICC TRIAL Intensive versus standard physical rehabilitation therapy in the critically illl parallel-group, assessor-blinded, randomized controlled trial Objective: To determine improvement in long-term clinical outcomes with Increased intensity ICU-based physical rehabilitation therapy as compared with standard therapy. 308 Inclusion criteria: Patients >18 years who received 48 hours of either invasive or non-invasive ventilation patients […]

TRANSFUSE Trial Summary: Age of RBCs for Transfusion in Critically Ill

2017 TRANSFUSE TRIAL Age of red cells(RBC) for transfusion and outcomes in critically ill adults Multicenter, randomized, double-blind trial Objective: To determine the effects of duration of RBC storage on mortality after transfusion among critically ill adults. 4994 patients Inclusion criteria: Patients >18 years of age or older who were admitted to a participating ICU, […]

RECONNECT Trial Summary: Mechanical Ventilation After Successful Spontaneous Breathing Trial

2017 RECONNECT TRIAL Reconnection to mechanical ventilation (MV) for 1h after a successful spontaneous breathing trial (SBT) reduces reintubation in critically ill patients. Parallel, two-arm, prospective randomised controlled trial Objective: To evaluate the reduction in need for reintubation in critically ill patients who pass a SBT by 1-hour rest compared with immediate extubation (control) 470 […]