2020 2020 LOCO2 TRIAL M Liberal or conservative oxygen therapy for Acute Respiratory Distress Syndrome Multicentre, randomised controlled trial Objective: To assess whether in patients with Acute Respiratory Distress Syndrome (ARDS), does conservative (Target PaO2:55-70mmHg; SpO2: 88-92%) vs. liberal (Target … Read More
ICU
MIDAS Trial Summary: Midodrine for Vasopressor Weaning
2020 MIDAS TRIAL: Effect of midodrine versus placebo on time to vasopressor discontinuation in patients with persistent hypotension in the intensive care unit Multi-centre, randomised, double-blind, placebo-controlled trial Objective: To investigate whether the administration of midodrine, an oral al-adrenergic agonist, … Read More
EAT-ICU Trial Summary: Early Goal-Directed Nutrition in ICU Patients
2017 EAT-ICU TRIAL: Early goal-directed nutrition versus standard of care in adult intensive care patients Single centre, blinded, randomised controlled trial Objective: To evaluate the effects of early goal-directed nutrition (EGDN) vs. standard nutritional care in adult ICU patients. 203 … Read More
EPICC Trial Summary: Intensive Physical Rehabilitation in Critically ill
2017 EPICC TRIAL Intensive versus standard physical rehabilitation therapy in the critically illl parallel-group, assessor-blinded, randomized controlled trial Objective: To determine improvement in long-term clinical outcomes with Increased intensity ICU-based physical rehabilitation therapy as compared with standard therapy. 308 Inclusion … Read More
ICE CUB 2 Trial Summary: Systematic ICU Triage in Critically Ill Patients
2017 ICE-CUB 2 TRIAL : Effect of systematic intensive care unit triage on long-term mortality among critically ill elderly patients in France Multicenter,cluster-randomized clinical trial Objective: To determine reduction in 6-month mortality in critically ill elderly patients by recommending systematic … Read More
LOVIT Trial Summary: IV Vitamin C in Septic Shock
2022 LOVIT TRIAL Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit Randomized, placebo-controlled trial Objective: To assess the use of intravenous vitamin C in a dults with sepsis who were receiving vasopressor therapy in the intensive … Read More