2022 PADN-CFDA TRIAL Pulmonary artery denervation for pulmonary arterial hypertension (PAH) multicenter, sham-controlled single-blind, randomized controlled trial Objective: To evaluate the treatment effects of pulmonary artery denervation (PADN) among patients with Group I PAH who were not on PAH-specific drugs … Read More
Cardiovascular Disease
PERSPECTIVE Trial Summary: Sacubitril/valsartan Effect on Cognition in HFpEF
2022 PERSPECTIVE TRIAL M Efficacy and safety of sacubitril/valsartan compared to valsartan on cognitive function in patients with chronic heart failure and preserved ejection fraction parallel, randomized controlled trial Objective: To evaluate the effectiveness of sacubitril/valsartan compared with valsartan alone … Read More
POPular AGE Trial Summary: Antiplatelet agent in NSTEMI
2020 POPULAR AGE TRIAL Clopidogrel versus ticagrelor or prasugrel in patients aged 70 years or older with non-ST-elevation acute coronary syndrome multicenter, randomized controlled trial Objective: To evaluate the effectiveness of clopidogrel compared with ticagrelor or prasugrel among patients ≥70 … Read More
A-HEFT Trial Summary: Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure
2004 -0.1 3.1 A-HEFT TRIAL Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure Inclusion criteria: patients self-identified as 1,050 black (of African descent) with NYHA class III-IV patients HF ≥3 months on standard therapy, including ACEI/ARBs, ẞ-blockers, … Read More
AATAC Trial Summary: Ablation vs. amiodarone for Persistent Atrial Fibrillation
2016 AATAC TRIAL Ablation vs. amiodarone for treatment of persistent atrial fibrillation in CHF Multicenter, parallel-group, open-label, randomized Objective: To assess if AF ablation is superior to y amiodarone in patients with symptomatic (NYHA II-III) heart failure with reduced ejection … Read More
ACCOMPLISH Trial: Benazepril + Amlodipine or HCTZ for Hypertension
2008 ACCOMPLISH TRIAL Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension in High-Risk Patients Multi-centered, double-blind, randomized, controlled trial Objective: To evaluate the effect of amlodipine vs. hydrochlorothiazide in patients with hypertension and at high risk for cardiovascular disease. E 11,506 … Read More
ACCORD BP Trial Summary: Intensive BP Control in Type 2 Diabetes
2010 ACCORD BP TRIAL Effects of intensive blood-pressure control in type 2 diabetes mellitus Multicenter, randomized, controlled, open-label trial Objective: In patients with T2DM at high risk for CV events, does intensive BP control (SBP <120 mmHg) reduce rates of … Read More
3SITES Trial Summary: Central Venous Catheterization Insertion Site
2015 3SITES TRIAL Intravascular complications of central venous catheterization by insertion site Multicenter, randomized controlled trial Objective: To evaluate the risk of catheter related bloodstream infection or symptomatic catheter related deep-vein thrombosis in an adult patient who had been admitted … Read More
3CPO Trial Summary: Noninvasive Ventilation in Pulmonary Edema
2008 3CPO TRIAL Noninvasive Ventilation in Acute Cardiogenic Pulmonary Edema multicenter, open, prospective, randomized, controlled trial Objective: To determine whether noninvasive ventilation reduces mortality and whether there are important differences in outcome associated with the method of treatment (CPAP or … Read More
TAVR with Self-Expanding Prosthesis Trial Summary
2014 COREVALVE HIGH-RISK TRIAL Transcatheter aortic-valve replacement (TAVR) with a self-expanding prosthesis Multicenter, randomized, non inferiority trial “‘Objective: To compare TAVR using a self-expanding a transcatheter aortic-valve bioprosthesis, with surgical aortic-valve replacement in patients with severe aortic stenosis & an … Read More