TAME Trial Summary The TAME trial investigated the impact of mild hypercapnia versus normocapnia on neurologic outcomes in adults with coma who were resuscitated after out-of-hospital cardiac arrest. Current guidelines recommend normocapnia, but mild hypercapnia has been suggested to enhance cerebral blood flow and potentially improve neurologic outcomes. The trial randomly assigned adults admitted to […]
Category: Emergency Medicine
ACUTE Trial Summary: TEE-Guided Cardioversion for AFib
2001 ACUTE TRIAL Use of transesophageal echocardiography to guide cardioversion in patients with atrial fibrillation multicenter, prospective, randomized controlled trial Objective: To compare conventional anticoagulation strategy with the transesophageal echocardiography to guide short-term anticoagulant therapy in patients with atrial fibrillation prescribed with electrical cardioversion 1222 patients Inclusion criteria: Patients aged ≥18 years who had atrial […]
CANARY Trial Summary: Cath vs AC in PE
2022 CANARY TRIAL Catheter-directed thrombolysis vs anticoagulation in patients with acute intermediate-high-risk pulmonary embolism parallel, open-label, randomized controlled trial Objective: To assess the effectiveness of catheter-directed thrombolysis (CCDT) compared with anticoagulation among intermediate- to high-risk individuals with acute pulmonary embolism 94 patients Inclusion criteria: Patients ≥18 years with acute pulmonary embolism presenting within 14 days […]
ICEREA Trial Summary: Endovascular Versus External TTM in Cardiac Arrest
2015 ICEREA TRIAL Endovascular versus external targeted temperature management for patients with out-of-hospital cardiac arrest multicenter, prospective, randomized controlled trial Objective: To evaluate if endovascular cooling is superior to external targeted temperature management in regards to favorable outcome after out-of-hospital cardiac arrest. 2 400 Inclusion criteria: Patients >18 to 79 years of age who had […]
POLAR Trial Summary: Prophylactic Hypothermia in Severe Traumatic Brain Injury
2018 POLAR TRIAL Prophylactic hypothermia for severe traumatic brain injury Multicentre, partially-blinded, randomised controlled trial Objective: To determine the effectiveness of early prophylactic hypothermia compared with normothermic management of patients after severe traumatic brain injury 511 patients Inclusion criteria: Intubated blunt trauma patients (or imminent intubation) between age 18-60 yrs with clinical diagnosis of severe […]
POKER Trial Summary: Propofol or Ketofol for Procedural Sedation
2016 POKER TRIAL Propofol or Ketofol for procedural sedation and analgesia in emergency medicine Randomised, double-blind clinical trial Objective: To determine whether an emergency physician-provided deep sedation with 1:1 combination of ketamine & propofol (ketofol) resulted in fewer adverse respiratory events requiring intervention than propofol alone for procedural sedation and analgesia 573 Inclusion criteria: Adult […]
SHoC-ED Trial Summary: POCUS in ER for Hypotension
2018 SHOC-ED TRIAL M Does point-of-care ultrasonography improve clinical outcomes in emergency department patients with undifferentiated hypotension? International, multicenter, randomized controlled trial Objective: To determine whether a standardised point-of-care D ultrasound (POCUS) protocol, compared with usual care, improves 30 day or hospital survival in selected non-trauma patients presenting to the ED with undifferentiated hypotension 273 […]
TTM 48 Trial Summary: TTM for 48 hours in Cardiac Arrest
2017 2017 TTM 48 TRIAL M Targeted Temperature Management for 48 vs 24 hours and neurologic outcome after out-of-Hospital Cardiac Arrest (OOHCA) Multicenter,blinded,parallel,pragmatic,randomized superiority trial Objective: To determine neurologic outcomes with Targeted Temperature Management (TTM) at 33°C for 48 hours as compared with standard 24-hours. 355 Inclusion criteria: Adults aged 18-80 y with OOHCA with […]
ARREST Trial: ECMO-facilitated Resuscitation in Refractory Cardiac Arrest
2020 ARREST 2020 TRIAL M Advanced reperfusion strategies for patients with out-of hospital cardiac arrest (OHCA) and refractory ventricular fibrillation (VF) Phase 2, single center, open-label, randomized clinical trial Objective: To compare implementation of early ECMO facilitated resuscitation compared to standard ACLS resuscitation in adults suffering out of hospital cardiac arrest (OHCA) presenting with an […]
Beta Blockers in Traumatic Brain Injury Trial Summary
2020 BETA-BLOCKER THERAPY IN TBI Beta-Blocker Therapy in Severe Traumatic Brain Injury (TBI) Single-center,non-blinded,randomized controlled trial d d Objective: To examine the effect of beta-blockers on outcomes in TBI patients. 154 patients Patients > 18 years with: -blunt head trauma & an intracranial injury with an AIS score of 3-5 requiring a surgical intervention within […]