2017 REVIVE TRIAL Effectiveness of an exercise programme on physical function in patients discharged from hospital following critical illness. | Multicentre, prospective phase II, randomised controlled trial Objective: To investigate the effectiveness of a 6 week exercise programme in patients … Read More
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REDUCE DELIRIUM Trial Summary: Haloperidol in Critically Ill at High Risk of Delirium
2017 2017 REDUCE-DELIRIUM TRIAL M Effect of haloperidol on survival among critically ill adults with a high risk of delirium | Randomized, double-blind, placebo-controlled trial Objective: To determine survival with prophylactic use of haloperidol among critically ill adults at high … Read More
PRECISE Trial Summary: Pregabalin for Acute and Chronic Sciatica
2017 PRECISE TRIAL Trial of pregabalin for acute and chronic sciatica Randomized, double-blind, placebo-controlled trial Objective: To determine whether pregabalin reduces the intensity of sciatica as compared to placebo 209 Inclusion criteria: Sciatica patients aged > 18 years having: – … Read More
POLAR Trial Summary: Prophylactic Hypothermia in Severe Traumatic Brain Injury
2018 POLAR TRIAL Prophylactic hypothermia for severe traumatic brain injury Multicentre, partially-blinded, randomised controlled trial Objective: To determine the effectiveness of early prophylactic hypothermia compared with normothermic management of patients after severe traumatic brain injury 511 patients Inclusion criteria: Intubated … Read More
POKER Trial Summary: Propofol or Ketofol for Procedural Sedation
2016 POKER TRIAL Propofol or Ketofol for procedural sedation and analgesia in emergency medicine Randomised, double-blind clinical trial Objective: To determine whether an emergency physician-provided deep sedation with 1:1 combination of ketamine & propofol (ketofol) resulted in fewer adverse respiratory … Read More
PLUS Trial Summary: Balanced Multielectrolyte Solution in Critically Ill
2022 PLUS TRIAL Balanced multi electrolyte solution versus saline in critically ill adults Investigator initiated, double-blind, parallel-group, randomised controlled trial d a Objective: To assess whether the use of balanced multielectrolyte solution (BMES) in preference to 0.9% sodium chloride solution … Read More
IPASS Trial Summary: Gefitinib or Carboplatin-Paclitaxel in Pulmonary Adenocarcinoma
2009 IPASS TRIAL Gefitinib or Carboplatin-Paclitaxel in Pulmonary Adenocarcinoma phase 3, multicenter, open-label, parallel-group, randomised controlled trial d a Objective: To assess the effect of gefitinib as compared with carboplatin-paclitaxel for adenocarcinoma of the lung in nonsmokers or former light … Read More
SHoC-ED Trial Summary: POCUS in ER for Hypotension
2018 SHOC-ED TRIAL M Does point-of-care ultrasonography improve clinical outcomes in emergency department patients with undifferentiated hypotension? International, multicenter, randomized controlled trial Objective: To determine whether a standardised point-of-care D ultrasound (POCUS) protocol, compared with usual care, improves 30 day … Read More
TRICOP Trial Summary: Transfusion strategy in critically ill Oncologic patients
2017 2017 TRICOP TRIAL Liberal vs restrictive transfusion strategy in critically ill oncologic patients: The transfusion requirements in critically ill oncologic Single-center, randomized, double-blind controlled trial Objective: To assess whether a restrictive strategy of RBC transfusion reduces 28-day mortality when … Read More
WOMAN Trail Summary: Early tranexamic acid in post-partum hemorrhage
2018 WOMAN TRIAL Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage Randomised, double-blind, placebo-controlled trial Objective: To determine whether early administration of tranexamic acid reduces death from bleeding in women with … Read More