2022 HEAL TRIAL Trial of Erythropoietin for Hypoxic-Ischemic Encephalopathy in Newborns phase 3 double-blind, placebo-controlled, randomised controlled trial Objective: To assess the role of erythropoietin in conjunction with therapeutic hypothermia for neuroprotection in newborn infants with hypoxic-ischemic encephalopathy 501 Inclusion … Read More
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TICH-2 Trial Summary: Tranexamic acid for IntraCerebral Haemorrhage
2018 TICH-2 TRIAL Tranexamic acid for hyperacute primary intracerebral haemorrhage Double blind, randomised, placebo-controlled, phase 3 superiority trial Objective: To assess whether tranexamic acid reduces haematoma expansion and improves outcome in adults with stroke due to intracerebral haemorrhage 3 2325 … Read More
TESTING Trial Summary: Methylprednisolone in IgA Nephropathy
2022 TESTING TRIAL Effect of oral Methylprednisolone on clinical outcomes in patients with IgA nephropathy Multicenter, investigator-initiated, double-blind, randomized clinical trial Objective: To evaluate the efficacy and safety of corticosteroids in patients with IgA nephropathy at risk of progression as … Read More
SPARK Trial Summary: Furosemide in critically ill patients with early AKI
2017 SPARK TRIAL The effect of low-dose furosemide in critically illl patients with early acute kidney injury (AKI) Pilot, multicenter, randomized, double-blinded, placebo-controlled trial Objective: To evaluate the impact of furosemide in early AKI on worsening AKI, kidney recovery and … Read More
SMART-MED Trial Summary: Balanced Crystalloids versus Saline in Critically Ill
2018 SMART-MED & SMART-SURG TRIAL Balanced crystalloids versus saline in critically ill adults Pragmatic, unblinded, cluster-randomized, multiple-crossover trial Objective: To determine whether administration of balanced crystalloids reduce a 30 day composite outcome of death, new renal replacement therapy or persistent … Read More
PARTNER Trial Summary: Family-Support Intervention in ICU
2018 PARTNER TRIAL A Randomized trial of a Family-support intervention in intensive care units Multicenter, stepped-wedge, cluster-randomized trial Objective: To compare a multicomponent family-support intervention delivered by the interprofessional ICU team with usual care 1420 Inclusion criteria: Patients >18 years … Read More
REVIVE Trial Summary: Exercise Program in Critically Ill after Discharge
2017 REVIVE TRIAL Effectiveness of an exercise programme on physical function in patients discharged from hospital following critical illness. | Multicentre, prospective phase II, randomised controlled trial Objective: To investigate the effectiveness of a 6 week exercise programme in patients … Read More
REDUCE DELIRIUM Trial Summary: Haloperidol in Critically Ill at High Risk of Delirium
2017 2017 REDUCE-DELIRIUM TRIAL M Effect of haloperidol on survival among critically ill adults with a high risk of delirium | Randomized, double-blind, placebo-controlled trial Objective: To determine survival with prophylactic use of haloperidol among critically ill adults at high … Read More
PRECISE Trial Summary: Pregabalin for Acute and Chronic Sciatica
2017 PRECISE TRIAL Trial of pregabalin for acute and chronic sciatica Randomized, double-blind, placebo-controlled trial Objective: To determine whether pregabalin reduces the intensity of sciatica as compared to placebo 209 Inclusion criteria: Sciatica patients aged > 18 years having: – … Read More
POLAR Trial Summary: Prophylactic Hypothermia in Severe Traumatic Brain Injury
2018 POLAR TRIAL Prophylactic hypothermia for severe traumatic brain injury Multicentre, partially-blinded, randomised controlled trial Objective: To determine the effectiveness of early prophylactic hypothermia compared with normothermic management of patients after severe traumatic brain injury 511 patients Inclusion criteria: Intubated … Read More