2006 APAF STUDY A randomized trial of circumferential pulmonary vein ablation versus antiarrhythmic drug therapy in paroxysmal atrial fibrillation (AF) randomized controlled trial M Objective: To compare the relative efficacy of circumferential pulmonary vein ablation (CPVA) & antiarrhythmic drug … Read More
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ANTLER Trial: Antidepressants in Primary care
2021 ANTLER TRIAL Maintenance or discontinuation of antidepressants in primary care Multicenter, randomized, double-blind trial M Objective: To assess the effects of maintenance antidepressant therapy, as compared with discontinuation of treatment, in patients taking antidepressants 478 patients Inclusion criteria: … Read More
ANTHARTIC Trial: Preventing VAP after CA
2019 ANTHARTIC TRIAL M Prevention of early Ventilator-Associated Pneumonia after cardiac arrest Multicentre, randomised, double-blind, placebo-controlled Objective: To investigate whether in post out-of-hospital cardiac arrest (OOHCA) patients treated with targeted temperature management, does the use of empirical antibiotics prevent early … Read More
ANT 005 TKA Trial: Abelacimab for VTE
2021 ANT-005 TKA TRIAL M Abelacimab for Prevention of Venous Thromboembolism (VTE) Phase 2,open-label, prospective randomized trial 400 Objective: To compare the efficacy & safety of abelacimab administered postoperatively with the efficacy & safety of enoxaparin in patients undergoing … Read More
ANRS IPERGAY Trial: Prophylaxis in men at risk of HIV
2015 ANRS IPERGAY TRIAL On-demand preexposure prophylaxis in men at high risk for HIV-1 infection Multicenter randomized, placebo controlled trial Objective: To assess if on-demand pre-exposure prophylaxis around the time of sex reduce the transmission of HIV Among men who … Read More
ANDROMEDA SHOCK Trial: Resuscitation in Septic Shock
ANDROMEDA-SHOCK: Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels in Septic Shock Multicenter, randomized trial conducted at 28 intensive care units in 5 countries 424 patients with septic shock were randomized to to a step-by-step … Read More
Amulet IDE Trial: Amulet LAA closure device vs. Watchman for Stroke ppx
2021 AMULET IDE TRIAL Amplatzer Amulet left atrial appendage occluder versus watchman device for stroke prophylaxis multicenter, open label, prospective, randomized controlled trial M Objective: To evaluate the safety & effectiveness of the dual-seal mechanism of the Amulet left atrial … Read More
AMPLITUDE-O Trial: CV and Renal Outcomes with Efpeglenatide
2021 AMPLITUDE-O TRIAL M Cardiovascular and renal outcomes with efpeglenatide in type 2 diabetes international, randomized, controlled trial Objective: To evaluate efpeglenatide in participants with type 2 diabetes and either a history of cardiovascular disease or current kidney disease 4076 … Read More
AMPLIFY Trial: Apixaban for acute VTE
2013 AMPLIFY TRIAL Oral Apixaban for the Treatment of Acute Venous Thromboembolism double-blind, multicenter, randomized controlled trial IM Objective: To determine if apixaban is non-inferior to conventional therapy with LMWH in patients with pulmonary embolism or proximal deep venous thrombosis … Read More
AMBITION Trial: Liposomal amphotericin B in Cryptococcal meningitis
2022 AMBITION TRIAL Single-dose liposomal amphotericin B treatment for cryptococcal meningitis Open-label, phase 3, non inferiority, randomized controlled trial M Objective: To determine the efficacy and safety of single high dose (10mg/kg) of liposomal amphotericin B in HIV-positive adults with … Read More