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INVICTUS Trial Summary: Rivaroxaban in Rheumatic Heart Disease–Associated AFib

2022 INVICTUS TRIAL Rivaroxaban in rheumatic heart disease associated atrial fibrillation (AF) Prospective, parallel group, open-label, randomized clinical trial d e Objective: To evaluate Rivaroxaban compared with Vitamin K antagonist among patients with rheumatic heart disease & atrial fibrillation antagonis … Read More

SODIUM-HF Trial Summary: Reduction of dietary sodium in Heart Failure

2022 SODIUM-HF TRIAL Reduction of dietary sodium to less than 100 mmol in heart failure International, open-label, randomised, controlled trial Objective: To evaluate if a low-sodium diet (<1500 mg daily) compared to usual care in ambulatory patients with heart failure … Read More

Cut-off Haemofiltration With Standard Haemofiltration in Acute Renal Failure

2018 HIGH VS STANDARD CUTOFF HEMOFILTRATION IN AKI A Double-Blind RCT of High cutoff versus Standard Hemofiltration in critically ill patients with Acute Kidney Injury (AKI) Single-center, double-blind, randomized controlled trial Objective: To assess impact of High cutoff hemofilter versus … Read More

HEAL Trial Summary: Erythropoietin for Hypoxic–Ischemic Encephalopathy in Newborns

2022 HEAL TRIAL Trial of Erythropoietin for Hypoxic-Ischemic Encephalopathy in Newborns phase 3 double-blind, placebo-controlled, randomised controlled trial Objective: To assess the role of erythropoietin in conjunction with therapeutic hypothermia for neuroprotection in newborn infants with hypoxic-ischemic encephalopathy 501 Inclusion … Read More

TICH-2 Trial Summary: Tranexamic acid for IntraCerebral Haemorrhage

2018 TICH-2 TRIAL Tranexamic acid for hyperacute primary intracerebral haemorrhage Double blind, randomised, placebo-controlled, phase 3 superiority trial Objective: To assess whether tranexamic acid reduces haematoma expansion and improves outcome in adults with stroke due to intracerebral haemorrhage 3 2325 … Read More

TESTING Trial Summary: Methylprednisolone in IgA Nephropathy

2022 TESTING TRIAL Effect of oral Methylprednisolone on clinical outcomes in patients with IgA nephropathy Multicenter, investigator-initiated, double-blind, randomized clinical trial Objective: To evaluate the efficacy and safety of corticosteroids in patients with IgA nephropathy at risk of progression as … Read More

SPARK Trial Summary: Furosemide in critically ill patients with early AKI

2017 SPARK TRIAL The effect of low-dose furosemide in critically illl patients with early acute kidney injury (AKI) Pilot, multicenter, randomized, double-blinded, placebo-controlled trial Objective: To evaluate the impact of furosemide in early AKI on worsening AKI, kidney recovery and … Read More

SMART-MED Trial Summary: Balanced Crystalloids versus Saline in Critically Ill

2018 SMART-MED & SMART-SURG TRIAL Balanced crystalloids versus saline in critically ill adults Pragmatic, unblinded, cluster-randomized, multiple-crossover trial Objective: To determine whether administration of balanced crystalloids reduce a 30 day composite outcome of death, new renal replacement therapy or persistent … Read More

PARTNER Trial Summary: Family-Support Intervention in ICU

2018 PARTNER TRIAL A Randomized trial of a Family-support intervention in intensive care units Multicenter, stepped-wedge, cluster-randomized trial Objective: To compare a multicomponent family-support intervention delivered by the interprofessional ICU team with usual care 1420 Inclusion criteria: Patients >18 years … Read More

REVIVE Trial Summary: Exercise Program in Critically Ill after Discharge

2017 REVIVE TRIAL Effectiveness of an exercise programme on physical function in patients discharged from hospital following critical illness. | Multicentre, prospective phase II, randomised controlled trial Objective: To investigate the effectiveness of a 6 week exercise programme in patients … Read More