2017 AIDA TRIAL Bioresorbable scaffolds versus metallic stents in routine PCI Prospective, multi-center, single-blind, randomized controlled trial M Objective: To assess if bioresorbable scaffolds superior to standard drug-eluting stents (DES) with regard to target-vessel failure in patients with stable or … Read More
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AIDA-WP2 Trial Summary: Fosfomycin or Nitrofurantoin in UTI
2018 AIDA-WP2 Effect of 5-Day nitrofurantoin vs single-dose fosfomycin on M clinical resolution of uncomplicated lower urinary tract infection in women Multinational, open-label, analyst-blinded, randomized clinical trial Objective: To compare the clinical and microbiologic efficacy of nitrofurantoin and fosfomycin in … Read More
AGE Trial Summary: Mammogram Screening for Breast Cancer
AGE: Effect of mammographic screening from age 40 years on breast cancer mortality Multicenter, open label randomized comparative trial Objective: To assess if initiation of breast cancer screening with mammograms at age 40-41 reduces breast cancer mortality Women age 39-41 … Read More
AFIRE Trial Summary: Antithrombotics in AFib and CAD
2019 AFIRE TRIAL Antithrombotic Therapy for Atrial Fibrillation with Stable Coronary Disease Multicenter, open-label trial conducted in Japan Objective: To evaluate the use of antithrombotic therapy in patients with atrial fibrillation and stable coronary artery disease. 2236 patients 4.14 Inclusion … Read More
AFFIRM Trial Summary: Rate vs Rhythm Control for AFib
AFFIRM Trial: A Comparison of Rate Control and Rhythm Control in Patients with Atrial Fibrillation Multicenter, parallel-group, randomized, controlled trial Objective: Among patients with atrial fibrillation and a high risk of stroke or death, what are the effects of rate … Read More
AF-CHF Trial Summary: Rhythm vs Rate Control for AFib and HF
AF-CHF: Rhythm Control versus Rate Control for Atrial Fibrillation and Heart Failure Multicenter, prospective, randomized, controlled trial Objective: To assess if rhythm-control reduce CV mortality in patients with AF and HFrEF as compared to rate control. Patients with AF and … Read More
ADRENAL Trial Summary: Steroids in Septic Shock
ADJUNCTIVE GLUCOCORTICOID THERAPY IN PATIENTS WITH SEPTIC SHOCK – THE ADRENAL TRIAL Multicenter, double-blind, parallel-group, randomized, controlled trial 3,658 patients with septic shock requiring vasopressors and mechanical ventilation were randomized to VS Hydrocortisone Placebo (n=1,832) (n=1,826) Mean follow-up: 90 Days … Read More
ADVANCE Trial Summary: Intensive Glucose Control in Diabetes Type 2
2008 ADVANCE TRIAL Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes Multicenter, factorial, randomized trial Objective: To evaluate vascular effects of intensive glycemic therapy targeting a HbA1c <6.5% in patients with type II diabetes 11,140 … Read More
ACCORD Trial: Intensive Glucose Lowering in DM2
ACCORD: Effects of Intensive Glucose Lowering in Type 2 Diabetes Multicenter, double-blinded, two-by-two factorial, randomized controlled trial Objective: To assess if intensive glycemic control targeting a HbA1c <6% versus standard glycemic control targeting a HbA1c 7-7.9% reduce the risk of … Read More
ACTT-2 Trial Summary: Baricitinib + Remdesivir in Covid-19
2020 ACTT-2 TRIAL Baricitinib plus Remdesivir for Hospitalized Adults with Covid-1 Double-blind, randomized, placebo-controlled trial M Objective: To compare the clinical efficacy of combination of baricitinib plus remdesivir with remdesivir alone among hospitalized adults with laboratory-confirmed Covid-19. 1033 patients Patients … Read More