Author Archives: admin

ALLIANCE Trial Summary: Axillary Dissection in Breast Cancer

2020 ALLIANCE TRIAL Effect of axillary dissection vs no axillary dissection on 10-year overall survival among women with invasive breast cancer and sentinel node metastasis Multicenter, phase 3, randomized controlled trial M Objective: To determine whether the 10-year overall survival … Read More

ALLHAT-LLT Trial Summary: Pravastatin in Moderate HLD

2002 ALLHAT-LLT Pravastatin vs Usual Care in Moderately Hypercholesterolemic, Hypertensive Patients Multicenter, randomized, nonblinded trial M Objective: To determine whether pravastatin compared with usual care reduces all-cause mortality in older, moderately hypercholes- terolemic, hypertensive participants with at least 1 additional … Read More

ALIVE Trial Summary: Amiodarone or Lidocaine in VFib

2002 ALIVE TRIAL Amiodarone as Compared with Lidocaine for Shock-Resistant Ventricular Fibrillation Prospective, randomized, controlled, double-dummy trial Objective: To determine whether amiodarone compared with lidocaine could improve survival rates to hospital admission in patients with shock-refractory, out-of-hospital cardiac arrest. 344 … Read More

ALEX Trial Summary: Alectinib vs. Crizotinib in NSCLC

2017 ALEX TRIAL Alectinib versus crizotinib in untreated ALK-positive non-small-cell lung cancer international, open-label, randomised phase 3 trial Σ Objective: To compare alectinib (600 mg twice daily) with crizotinib in patients with previously untreated, advanced ALK-positive NSCLC, including those with … Read More

ALCOHOL-AF Trial Summary: Alcohol and AFib

2019 ALCOHOL-AF TRIAL Impact of Alcohol Abstinence in Moderate Drinkers With Atrial Fibrillation Randomized clinical trial Objective: To evaluate abstinence from alcohol compared with usual consumption among patients with atrial fibrillation and moderate alcohol consumption. 140 bel 53 5.6 9 … Read More

Alcohol Abstinence in AFib Clinical Trial Summary

2020 ALCOHOL ABSTINENCE IN ATRIAL FIBRILLATION multicenter, prospective, open-label, randomized, controlled trial Objective: To assess the effect of abstinence from alcohol on secondary prevention of atrial fibrillation 140 patients Inclusion criteria: age of 18 to 85 years, presence of symptomatic … Read More

Albumin in Cirrhosis and SBP Clinical Trial

Effect of Intravenous Albumin on Renal Impairment and Mortality in Patients with Cirrhosis and Spontaneous Bacterial Peritonitis Multi-center, open-label (analyst-blinded), randomised controlled trial Objective: To assess use of IV albumin for reducing renal impairment and mortality when compared to antibiotics … Read More

ALBIOS Trial Summary: Albumin in Septic Shock

ALBUMIN REPLACEMENT IN PATIENTS WITH SEVERE SEPSIS OR SEPTIC SHOCK – THE ALBIOS TRIAL Multicenter, open-label, randomized trial Patients with severe sepsis 1,818 or septic shock were randomized to Albumin to maintain serum albumin ≥3 g/dL vs (n=910) No albumin … Read More

AKIKI 2 Trial Summary: RRT for Severe AKI

2021 AKIKI 2 TRIAL Comparison of two delayed strategies for renal replacement therapy initiation for severe AKI Multicentre, open-label, randomised, controlled trial Objective: To test the hypothesis that a more-delayed initiation strategy would result in more RRT-free days, compared with … Read More

AIRTRIP Trial Summary: Anakinra in Recurrent Pericarditis

2016 AIRTRIP TRIAL Effect of anakinra on recurrent pericarditis among patients with colchicine resistance and dependance M Multicenter, double-blind, placebo-controlled, open-label, medication withdrawal study Objective: To determine the efficacy of anakinra for colchicine-resistant and corticosteroid-dependent recurrent pericarditis 21 Inclusion criteria: … Read More