VOYAGER PAD Trial Summary The VOYAGER PAD trial aimed to assess the efficacy and safety of rivaroxaban, a factor Xa inhibitor, in patients with peripheral artery disease (PAD) who had undergone lower-extremity revascularization. Patients with PAD who have undergone revascularization … Read More
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WAKE-UP Trial: MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset
WAKE-UP Trial Summary The WAKE-UP trial aimed to investigate the potential benefits of intravenous alteplase, a thrombolytic agent, in treating acute stroke patients with an unknown time of onset. Current guidelines recommend intravenous thrombolysis only if the time since symptom … Read More
WARFASA Trial: Aspirin for Preventing the Recurrence of VTE
WARFASA Trial Summary The WARFASA trial aimed to evaluate the effectiveness of aspirin in preventing recurrent venous thromboembolism (VTE) in patients who had previously experienced an unprovoked VTE event. Approximately 20% of patients with unprovoked VTE experience a recurrence within … Read More
WASID Trial Summary: Warfarin and Aspirin for Symptomatic Intracranial Arterial Stenosis
WASID Trial Summary The WASID trial sought to compare the effectiveness of warfarin and aspirin in the treatment of atherosclerotic intracranial arterial stenosis, a significant cause of stroke. While warfarin is often preferred over aspirin for this condition, the two … Read More
WATERFALL Trial Summary: Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis
WATERFALL Trial Summary The WATERFALL trial aimed to evaluate the effectiveness and safety of early aggressive hydration in the management of acute pancreatitis. While early aggressive hydration is a commonly recommended approach, limited evidence exists to support this practice. Conducted … Read More
WHiTE 5 Trial Summary: Cemented or Uncemented Hemiarthroplasty for Hip Fracture
WHiTE 5 Trial Summary The WHiTE5 trial, a multicenter, randomized, controlled trial, has provided valuable insights into the use of bone cement in hip fractures treated with hemiarthroplasty. The trial aimed to compare the health-related quality of life and outcomes … Read More
WOEST Trial Summary: Clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing PCI
WOEST Trial Summary The WOEST trial, a groundbreaking study published in The Lancet, has shed light on a significant issue faced by patients undergoing percutaneous coronary intervention (PCI) while taking oral anticoagulants. Traditionally, triple therapy involving aspirin and clopidogrel has … Read More
WOMAN Trial Summary: Early tranexamic acid in women with post-partum haemorrhage
WOMAN Trial: The Use of Tranexamic Acid in Reducing Death Due to Post-Partum Haemorrhage Post-partum haemorrhage (PPH) is a leading cause of maternal mortality worldwide. The administration of tranexamic acid has been shown to decrease bleeding-related deaths in trauma patients. … Read More
WOSCOPS Trial: Pravastatin’s Role in Reducing the Incidence of MI and Death
WOSCOPS Trial Summary “The WOSCOPS Trial: Pravastatin’s Role in Reducing the Incidence of Myocardial Infarction and Death from Cardiovascular Causes” The West of Scotland Coronary Prevention Study (WOSCOPS) has significantly contributed to our understanding of the role of pravastatin in … Read More
WRAP-IT Trial: Utilizing Antibiotic-Eluting Envelopes to Reduce Infections After Cardiac Device Implantation
WRAP-IT Trial Summary Infections following the placement of cardiac implantable electronic devices (CIEDs) can lead to significant morbidity and mortality. Although preoperative antibiotics are a standard prophylactic strategy, evidence for other preventive approaches is limited. The WRAP-IT trial sought to … Read More