2021 PALACS TRIAL M Posterior left pericardiotomy for the prevention of postoperative atrial fibrillation after cardiac surgery Randomized, parallel, stratified, single-centre study Objective: To evaluate posterior left pericardiotomy compared with no intervention among patients undergoing open heart surgery 420 patients … Read More
Cardiovascular Disease
ANTHARTIC Trial Summary: Prevention of Ventilator-Associated Pneumonia after Cardiac Arrest
2019 ANTHARTIC TRIAL M Prevention of early Ventilator-Associated Pneumonia after cardiac arrest Multicentre, randomised, double-blind, placebo-controlled Objective: To investigate whether in post out-of-hospital cardiac arrest (OOHCA) patients treated with targeted temperature management, does the use of empirical antibiotics prevent early … Read More
VAM-IHCA Trial Summary: Vasopressin and Methylprednisolone on ROSC after Cardiac Arrest
2021 VAM-IHCA TRIAL M Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients with In-Hospital Cardiac Arrest Multicenter, randomized, double-blind, placebo-controlled trial Objective: To determine whether the combination of vasopressin and methylprednisolone administered during in-hospital … Read More
ATACAS Trial Summary: Tranexamic Acid in Coronary Artery Surgery
2017 ATACAS TRIAL: Tranexamic Acid in patients undergoing coronary artery surgery Multicenter,2×2 factorial design, double-blind, randomized controlled trial Objective: To evaluate death risk and thrombotic complications with TXA among at-risk patients undergoing coronary artery surgery. 4662 Inclusion criteria: Patients >18 … Read More
TRANSFER AMI Trial Summary: Early Angioplasty after Fibrinolysis for Acute MI
2009 TRANSFER-AMI trial: Routine Early Angioplasty after Fibrinolysis for Acute Myocardial Infarction Multicenter, randomized, non-blinded, parallel Assignment Objective: To assess outcomes in patients with AMI treated with thrombolysis transferring to a center providing PCI for standard treatment (rescue PCI or … Read More
DISCHARGE Trial Summary: CT or Angio in Stable Chest Pain
2022 DISCHARGE TRIAL Summary: CT or Invasive Coronary Angiography in Stable Chest Pain- Pragmatic, randomized controlled trial- Objective: To evaluate computed tomography (CT) compared with invasive coronary angiography among patients with stable chest pain and intermediate pretest probability of obstructive … Read More
UK TAVI Trial Summary: TAVI in Moderate Aortic Stenosis
2022 UK TAVI TRIAL M Effect of TAVI vs Surgical Aortic Valve Replacement on All-Cause Mortality in Patients With Aortic Stenosis Multicenter, randomized controlled trial – Objective: To assess if TAVI is non-inferior to surgical aortic valve replacement in patients … Read More
PARADISE MI Trial Summary: Sacubitril-valsartan vs ramipril in acute MI
2021 PARADISE-MI M Angiotensin Receptor-Neprilysin Inhibition in Acute Myocardial Infarction international, multicenter, randomized, double-blind, active-comparator trial S S 1. Objective: To compare the effects of sacubitril-valsartan and angiotensin converting-enzyme inhibitor, ramipril in patients with acute myocardial infarction 5661 Inclusion criteria: … Read More