The TGC-Fast Trial, featured in the New England Journal of Medicine in 2023, was a multicenter, randomized, controlled trial that aimed to assess the benefits of tight glucose control without early parenteral nutrition in the intensive care unit (ICU). The … Read More
Critical Care
ECLS-SHOCK Trial: Extracorporeal Life Support in Cardiogenic Shock
The ECLS-SHOCK trial, as reported in the New England Journal of Medicine in 2023, was a multicenter, parallel, randomized controlled trial designed to evaluate the efficacy of extracorporeal life support (ECLS) in patients with acute myocardial infarction (MI) complicated by … Read More
AMIKINHAL Trial: Inhaled Amikacin in Preventing VAP
The medical world is continually seeking innovative methods to combat and prevent life-threatening conditions. One such condition is ventilator-associated pneumonia, a severe complication that affects patients undergoing mechanical ventilation. The recent AMIKINHAL trial, a multicenter, double-blind, randomized, controlled, superiority study, … Read More
VIOLET Trial: High-Dose Vitamin D3 for Critically Ill
VIOLET Trial Summary The VIOLET trial was a phase 3, randomized, double-blind, placebo-controlled study designed to evaluate the effects of early vitamin D3 supplementation in critically ill patients with vitamin D deficiency who were at high risk for death. Vitamin … Read More
TAME Trial: Mild Hypercapnia after Cardiac Arrest
TAME Trial Summary The TAME trial investigated the impact of mild hypercapnia versus normocapnia on neurologic outcomes in adults with coma who were resuscitated after out-of-hospital cardiac arrest. Current guidelines recommend normocapnia, but mild hypercapnia has been suggested to enhance … Read More
VITAMINS Trial Summary: Vit. C in Septic Shock
VITAMINS Trial Summary The VITAMINS trial aimed to determine whether the combination of vitamin C, hydrocortisone, and thiamine is more effective than hydrocortisone alone in expediting the resolution of septic shock. The trial included 216 patients with septic shock and … Read More
Navigating the Controversy: A Comprehensive Review of Landmark Clinical Trials on Steroids Use in Septic Shock
Explore the pivotal clinical trials that have shaped our understanding of the role of steroids in the management of septic shock, unveiling the complexities and nuances of this controversial topic. Introduction Septic shock is a life-threatening condition characterized by a … Read More
ANTHARTIC Trial: Preventing VAP after CA
2019 ANTHARTIC TRIAL M Prevention of early Ventilator-Associated Pneumonia after cardiac arrest Multicentre, randomised, double-blind, placebo-controlled Objective: To investigate whether in post out-of-hospital cardiac arrest (OOHCA) patients treated with targeted temperature management, does the use of empirical antibiotics prevent early … Read More
ANDROMEDA SHOCK Trial: Resuscitation in Septic Shock
ANDROMEDA-SHOCK: Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels in Septic Shock Multicenter, randomized trial conducted at 28 intensive care units in 5 countries 424 patients with septic shock were randomized to to a step-by-step … Read More
VICTAS Trial: Vitamin C, Thiamine, and Hydrocortisone in Sepsis
2021 VICTAS TRIAL IM Effect of vitamin C, thiamine, and hydrocortisone on ventilator-and vasopressor-free days in patients with sepsis multicenter, double-blind, randomized controlled trial Objective: To determine whether combination of vitamin C, thiamine & hydrocortisone every 6 hours increases ventilator- … Read More