2015 ANRS IPERGAY TRIAL On-demand preexposure prophylaxis in men at high risk for HIV-1 infection Multicenter randomized, placebo controlled trial Objective: To assess if on-demand pre-exposure prophylaxis around the time of sex reduce the transmission of HIV Among men who … Read More
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ANDROMEDA SHOCK Trial: Resuscitation in Septic Shock
ANDROMEDA-SHOCK: Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels in Septic Shock Multicenter, randomized trial conducted at 28 intensive care units in 5 countries 424 patients with septic shock were randomized to to a step-by-step … Read More
Amulet IDE Trial: Amulet LAA closure device vs. Watchman for Stroke ppx
2021 AMULET IDE TRIAL Amplatzer Amulet left atrial appendage occluder versus watchman device for stroke prophylaxis multicenter, open label, prospective, randomized controlled trial M Objective: To evaluate the safety & effectiveness of the dual-seal mechanism of the Amulet left atrial … Read More
AMPLITUDE-O Trial: CV and Renal Outcomes with Efpeglenatide
2021 AMPLITUDE-O TRIAL M Cardiovascular and renal outcomes with efpeglenatide in type 2 diabetes international, randomized, controlled trial Objective: To evaluate efpeglenatide in participants with type 2 diabetes and either a history of cardiovascular disease or current kidney disease 4076 … Read More
AMPLIFY Trial: Apixaban for acute VTE
2013 AMPLIFY TRIAL Oral Apixaban for the Treatment of Acute Venous Thromboembolism double-blind, multicenter, randomized controlled trial IM Objective: To determine if apixaban is non-inferior to conventional therapy with LMWH in patients with pulmonary embolism or proximal deep venous thrombosis … Read More
AMBITION Trial: Liposomal amphotericin B in Cryptococcal meningitis
2022 AMBITION TRIAL Single-dose liposomal amphotericin B treatment for cryptococcal meningitis Open-label, phase 3, non inferiority, randomized controlled trial M Objective: To determine the efficacy and safety of single high dose (10mg/kg) of liposomal amphotericin B in HIV-positive adults with … Read More
Wolf-Parkinson-White (WPW) Syndrome: Infographic
Wolff-Parkinson-White (WPW) Syndrome Characterized by presence of accessory pathway (bundle of Kent) between atria and ventricle that can cause “preexcitation” or earlier activation of the His-Purkinje system. ECG Features Delta wave: slow muscle- fiber-to-muscle-fiber conduction WPW pattern: Preexcitation pattern on … Read More
VICTAS Trial: Vitamin C, Thiamine, and Hydrocortisone in Sepsis
2021 VICTAS TRIAL IM Effect of vitamin C, thiamine, and hydrocortisone on ventilator-and vasopressor-free days in patients with sepsis multicenter, double-blind, randomized controlled trial Objective: To determine whether combination of vitamin C, thiamine & hydrocortisone every 6 hours increases ventilator- … Read More
ISCHEMIA Trial: Invasive or Medical therapy for Stable CAD
2020 ISCHEMIA TRIAL M Initial Invasive or Conservative Strategy for Stable Coronary Disease multicenter, parallel, randomized controlled trial Objective: Tto determine the effect of adding cardiac catheterization (hereafter, angiography) and revascularization when feasible to medical therapy in patients with stable … Read More
SINGLE Trial: Dolutegravir in HIV
2013 SINGLE TRIAL M Dolutegravir plus abacavir-lamivudine for the treatment of HIV-1 infection double-blind, randomized controlled trial 844 Objective: To assess the safety & efficacy of dolutegravir at a dose of 50 mg plus a fixed-dose combination of abacavir-lamivudine, as … Read More