2017 EPICC TRIAL Intensive versus standard physical rehabilitation therapy in the critically illl parallel-group, assessor-blinded, randomized controlled trial Objective: To determine improvement in long-term clinical outcomes with Increased intensity ICU-based physical rehabilitation therapy as compared with standard therapy. 308 Inclusion … Read More
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DREAMS Trial Summary: Dexamethasone for Post-op Nausea and Vomiting
2017 DREAMS TRIAL Dexamethasone vs standard treatment for postoperative nausea and vomiting (PONV) in gastrointestinal surgery Pragmatic, blinded, multicentre,randomised controlled trial Objective: To determine reduction in PONV by preoperative Dexamethasone in patients undergoing elective bowel surgery & its association with … Read More
ICE CUB 2 Trial Summary: Systematic ICU Triage in Critically Ill Patients
2017 ICE-CUB 2 TRIAL : Effect of systematic intensive care unit triage on long-term mortality among critically ill elderly patients in France Multicenter,cluster-randomized clinical trial Objective: To determine reduction in 6-month mortality in critically ill elderly patients by recommending systematic … Read More
INPRESS Trial Summary: Blood Pressure Management in Patients Undergoing Major Surgery
2017 INPRESS TRIAL Effect of individualized vs standard blood pressure management strategies on postoperative organ dysfunction among high-risk patients undergoing major surgery. Multicenter, randomized, parallel-group clinical trial Objective: To evaluate reduction in post-op organ dysfunction with Pan individualized BP management … Read More
TRANSFER AMI Trial Summary: Early Angioplasty after Fibrinolysis for Acute MI
2009 TRANSFER-AMI trial: Routine Early Angioplasty after Fibrinolysis for Acute Myocardial Infarction Multicenter, randomized, non-blinded, parallel Assignment Objective: To assess outcomes in patients with AMI treated with thrombolysis transferring to a center providing PCI for standard treatment (rescue PCI or … Read More
DIRECT MT Trial Summary: Thrombectomy with or without Alteplase in Stroke
2020 DIRECT-MT TRIAL: Endovascular thrombectomy with or without intravenous alteplase in acute stroke Investigator-initiated, multicentre, prospective, randomised, open-label trial Objective: To evaluate endovascular thrombectomy with or without intravenous alteplase in patients with acute ischemic stroke 656 patients Participants > 18 … Read More
CLASSIC Trial Summary: Restriction of IVF in Septic Shock
2022 CLASSIC TRIAL Restriction of Intravenous Fluid in ICU Patients with Septic Shock Multicenter, international, randomized controlled trial ca Objective: To investigate whether the restriction of Intravenous Fluid in ICU Patients with Septic Shock improves 90-day survival? unipro 1554 Patients … Read More
PRIME Care Trial Summary: Pharmacogenomic Testing for Drug-Gene Interactions in Depression Treatment
2022 PRIME CARE TRIAL Effect of Pharmacogenomic Testing for Drug-Gene Interactions on Medication Selection in Major Depressive Disorder Randomised, pragmatic, clinical trial Objective: To assess if pharmacogenomic testing for drug-gene interactions affects the selection of antidepressant medication and response in … Read More
SHENFU Trial Summary: Shenfu Injection After in hospital Cardiac Arrest
2017 SHENFU TRIAL Efficacy and safety of combination therapy of Shenfu injection and post-resuscitation bundle in patients with return of spontaneous circulation(ROSC) after in-hospital cardiac arrest Prospective,randomized controlled clinical study Objective:To evaluate the efficacy,safety & improvement in mortality of combined … Read More
TRANSFUSE Trial Summary: Age of RBCs for Transfusion in Critically Ill
2017 TRANSFUSE TRIAL Age of red cells(RBC) for transfusion and outcomes in critically ill adults Multicenter, randomized, double-blind trial Objective: To determine the effects of duration of RBC storage on mortality after transfusion among critically ill adults. 4994 patients Inclusion … Read More