2020 PEPTIC TRIAL Effect of stress ulcer prophylaxis with Proton pump inhibitors vs Histamine-2 receptor blockers on in-hospital mortality among ICU patients receiving invasive mechanical ventilation Pragmatic, open-label, cluster randomised crossover design trial Objective: To compare in-hospital mortality rates using … Read More
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VAM-IHCA Trial Summary: Vasopressin and Methylprednisolone on ROSC after Cardiac Arrest
2021 VAM-IHCA TRIAL M Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients with In-Hospital Cardiac Arrest Multicenter, randomized, double-blind, placebo-controlled trial Objective: To determine whether the combination of vasopressin and methylprednisolone administered during in-hospital … Read More
CHECK-UP Trial Summary: Ramped vs Sniffing Position for Intubation
2017 CHECK-UP: POSITION- Ramped position vs Sniffing position during endotracheal intubation of critically ill adults 2 x 2 factorial design,randomised, multicentre,pragmatic trial 9 5 Objective: To evaluate the reduction in incidence of oxygen desaturation in ramped position as compared to … Read More
ATACAS Trial Summary: Tranexamic Acid in Coronary Artery Surgery
2017 ATACAS TRIAL: Tranexamic Acid in patients undergoing coronary artery surgery Multicenter,2×2 factorial design, double-blind, randomized controlled trial Objective: To evaluate death risk and thrombotic complications with TXA among at-risk patients undergoing coronary artery surgery. 4662 Inclusion criteria: Patients >18 … Read More
MIDAS Trial Summary: Midodrine for Vasopressor Weaning
2020 MIDAS TRIAL: Effect of midodrine versus placebo on time to vasopressor discontinuation in patients with persistent hypotension in the intensive care unit Multi-centre, randomised, double-blind, placebo-controlled trial Objective: To investigate whether the administration of midodrine, an oral al-adrenergic agonist, … Read More
EAT-ICU Trial Summary: Early Goal-Directed Nutrition in ICU Patients
2017 EAT-ICU TRIAL: Early goal-directed nutrition versus standard of care in adult intensive care patients Single centre, blinded, randomised controlled trial Objective: To evaluate the effects of early goal-directed nutrition (EGDN) vs. standard nutritional care in adult ICU patients. 203 … Read More
EPICC Trial Summary: Intensive Physical Rehabilitation in Critically ill
2017 EPICC TRIAL Intensive versus standard physical rehabilitation therapy in the critically illl parallel-group, assessor-blinded, randomized controlled trial Objective: To determine improvement in long-term clinical outcomes with Increased intensity ICU-based physical rehabilitation therapy as compared with standard therapy. 308 Inclusion … Read More
DREAMS Trial Summary: Dexamethasone for Post-op Nausea and Vomiting
2017 DREAMS TRIAL Dexamethasone vs standard treatment for postoperative nausea and vomiting (PONV) in gastrointestinal surgery Pragmatic, blinded, multicentre,randomised controlled trial Objective: To determine reduction in PONV by preoperative Dexamethasone in patients undergoing elective bowel surgery & its association with … Read More
ICE CUB 2 Trial Summary: Systematic ICU Triage in Critically Ill Patients
2017 ICE-CUB 2 TRIAL : Effect of systematic intensive care unit triage on long-term mortality among critically ill elderly patients in France Multicenter,cluster-randomized clinical trial Objective: To determine reduction in 6-month mortality in critically ill elderly patients by recommending systematic … Read More
INPRESS Trial Summary: Blood Pressure Management in Patients Undergoing Major Surgery
2017 INPRESS TRIAL Effect of individualized vs standard blood pressure management strategies on postoperative organ dysfunction among high-risk patients undergoing major surgery. Multicenter, randomized, parallel-group clinical trial Objective: To evaluate reduction in post-op organ dysfunction with Pan individualized BP management … Read More